Reactome | MTA2 [nucleoplasm]

MTA2 [nucleoplasm]

Stable Identifier

R-SSC-4657009

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

MTA2, A0A8W4FG05

Locations in the PathwayBrowser

Expand all

Chromatin organization (Sus scrofa)

- Chromatin modifying enzymes (Sus scrofa)
  - HDACs deacetylate histones (Sus scrofa)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Sus scrofa)
      - HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Sus scrofa)
        
        MTA2 [nucleoplasm] (Sus scrofa)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Sus scrofa)
        
        HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Sus scrofa)
        
        MTA2 [nucleoplasm] (Sus scrofa)
    - HDAC1:2-containing complex deacetylate histones (Sus scrofa)
      - HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Sus scrofa)
        
        MTA2 [nucleoplasm] (Sus scrofa)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Sus scrofa)
        
        HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Sus scrofa)
        
        MTA2 [nucleoplasm] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase I Transcription (Sus scrofa)
  - RNA Polymerase I Promoter Clearance (Sus scrofa)
    - RNA Polymerase I Transcription Initiation (Sus scrofa)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Sus scrofa)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Sus scrofa)
        
        MTA2 [nucleoplasm] (Sus scrofa)
- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional Regulation by TP53 (Sus scrofa)
      - Regulation of TP53 Activity (Sus scrofa)
        
        Regulation of TP53 Activity through Acetylation (Sus scrofa)
        
        MTA2-NuRD complex deacetylates TP53 (Sus scrofa)
        
        MTA2-NuRD complex [nucleoplasm] (Sus scrofa)
        
        MTA2 [nucleoplasm] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - PIP3 activates AKT signaling (Sus scrofa)
    - PTEN Regulation (Sus scrofa)
      - Regulation of PTEN gene transcription (Sus scrofa)
        
        SALL4 recruits NuRD to PTEN gene (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Sus scrofa)
        
        MTA2 [nucleoplasm] (Sus scrofa)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Sus scrofa)
        
        SALL4:NuRD [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Sus scrofa)
        
        MTA2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A8W4FG05

Gene Names

MTA2

Reference Genes

BioGPS Gene:100515941 MTA2

ENSEMBL:ENSSSCG00000013062.5

KEGG:ssc:100515941 MTA2

Monarch:100515941 MTA2

NCBI Gene:100515941 MTA2

UCSC:A0A8W4FG05 MTA2

Reference Transcript

RefSeq:XM_003122622.4 MTA2

Other Identifiers

100515941

GO:0000118

GO:0000122

GO:0000781

GO:0003677

GO:0003682

GO:0003712

GO:0003713

GO:0003714

GO:0003824

GO:0004407

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0006306

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0016581

GO:0016787

GO:0036211

GO:0042826

GO:0043226

GO:0043565

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0061629

GO:0140096

GO:0140110

Ssc.19299.1.S1_at

Participates

as a component of

MTA2-NuRD complex [nucleoplasm] (Sus scrofa)

as a member of

MTA1, MTA2, MTA3 [nucleoplasm] (Sus scrofa)

Inferred From

MTA2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_003122670.2

ENSEMBL

ENSSSCT00000095787, ENSSSCG00000013062, ENSSSCP00000077800