Reactome | phospho-p-S172-IKBKE [cytosol]

phospho-p-S172-IKBKE [cytosol]

Stable Identifier

R-SSC-450278

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

M9MMN5

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - Toll-like Receptor Cascades (Sus scrofa)
    - Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
      - MyD88-independent TLR4 cascade (Sus scrofa)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
        
        Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Sus scrofa)
        
        IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Sus scrofa)
        
        p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        p-S172-IKBKE:p-S172-IKBKE [cytosol] (Sus scrofa)
        
        phospho-p-S172-IKBKE [cytosol] (Sus scrofa)
        
        IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Sus scrofa)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Sus scrofa)
        
        p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        p-S172-IKBKE:p-S172-IKBKE [cytosol] (Sus scrofa)
        
        phospho-p-S172-IKBKE [cytosol] (Sus scrofa)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Sus scrofa)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Sus scrofa)
        
        p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        p-S172-IKBKE:p-S172-IKBKE [cytosol] (Sus scrofa)
        
        phospho-p-S172-IKBKE [cytosol] (Sus scrofa)
        
        Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Sus scrofa)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Sus scrofa)
        
        p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        p-S172-IKBKE:p-S172-IKBKE [cytosol] (Sus scrofa)
        
        phospho-p-S172-IKBKE [cytosol] (Sus scrofa)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Sus scrofa)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Sus scrofa)
        
        p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        p-S172-IKBKE:p-S172-IKBKE [cytosol] (Sus scrofa)
        
        phospho-p-S172-IKBKE [cytosol] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Death Receptor Signaling (Sus scrofa)
  - TNF signaling (Sus scrofa)
    - Regulation of TNFR1 signaling (Sus scrofa)
      - TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Sus scrofa)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
        
        p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Sus scrofa)
        
        p-S172-IKBKE:p-S172-IKBKE [cytosol] (Sus scrofa)
        
        phospho-p-S172-IKBKE [cytosol] (Sus scrofa)
      - TBK1, IKBKE phosphorylate RIPK1 at T189 (Sus scrofa)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
        
        p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Sus scrofa)
        
        p-S172-IKBKE:p-S172-IKBKE [cytosol] (Sus scrofa)
        
        phospho-p-S172-IKBKE [cytosol] (Sus scrofa)
        
        TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
        
        p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Sus scrofa)
        
        p-S172-IKBKE:p-S172-IKBKE [cytosol] (Sus scrofa)
        
        phospho-p-S172-IKBKE [cytosol] (Sus scrofa)
        
        p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Sus scrofa)
        
        p-S172-IKBKE:p-S172-IKBKE [cytosol] (Sus scrofa)
        
        phospho-p-S172-IKBKE [cytosol] (Sus scrofa)
    - TNFR1-induced proapoptotic signaling (Sus scrofa)
      - TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Sus scrofa)
        
        TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Sus scrofa)
        
        p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Sus scrofa)
        
        p-S172-IKBKE:p-S172-IKBKE [cytosol] (Sus scrofa)
        
        phospho-p-S172-IKBKE [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:M9MMN5

Reference Genes

BioGPS Gene:100519508

ENSEMBL:ENSSSCG00000015644.6

KEGG:ssc:100519508

Monarch:100519508

NCBI Gene:100519508

UCSC:M9MMN5

Reference Transcript

Other Identifiers

GO:0000166

GO:0002218

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0005524

GO:0005634

GO:0005737

GO:0006468

GO:0006950

GO:0006955

GO:0006974

GO:0008384

GO:0008630

GO:0010467

GO:0010628

GO:0010884

GO:0016301

GO:0016605

GO:0016740

GO:0031625

GO:0031966

GO:0032481

GO:0034097

GO:0034340

GO:0035456

GO:0035556

GO:0036435

GO:0042802

GO:0043123

GO:0043254

GO:0048255

GO:0060337

GO:0060340

GO:0097400

GO:0098586

GO:0140096

Participates

as a component of

p-S172-IKBKE:p-S172-IKBKE [cytosol] (Sus scrofa)

Other forms of this molecule

phospho-monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]

phospho-p-S172-IKBKE [nucleoplasm]

K63polyUb-K30,K401-IKBKE [cytosol]

IKBKE [cytosol]

Inferred From

p-S172-IKBKE [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 172 (in Homo sapiens)

Coordinate

172

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_020918968.1, XP_020918967.1, XP_020918966.1

ENSEMBL

ENSSSCG00000015644, ENSSSCT00000030765, ENSSSCP00000019776

VGNC

89071

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