Reactome | GRIN2B [plasma membrane]

GRIN2B [plasma membrane]

Stable Identifier

R-SSC-419558

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

F1SQ84

Locations in the PathwayBrowser

Expand all

Neuronal System (Sus scrofa)

- Protein-protein interactions at synapses (Sus scrofa)
  - Synaptic adhesion-like molecules (Sus scrofa)
    - PSD-95 binds NMDA receptor (Sus scrofa)
      - NMDA receptor complex [plasma membrane] (Sus scrofa)
        
        NMDA receptor [plasma membrane] (Sus scrofa)
        
        NR2 subunits [plasma membrane] (Sus scrofa)
        
        GRIN2B [plasma membrane] (Sus scrofa)
      - NMDAR:PSD-95 [plasma membrane] (Sus scrofa)
        
        NMDA receptor complex [plasma membrane] (Sus scrofa)
        
        NMDA receptor [plasma membrane] (Sus scrofa)
        
        NR2 subunits [plasma membrane] (Sus scrofa)
        
        GRIN2B [plasma membrane] (Sus scrofa)
    - SALM1 binds NMDA receptor (Sus scrofa)
      - NMDAR:PSD-95 [plasma membrane] (Sus scrofa)
        
        NMDA receptor complex [plasma membrane] (Sus scrofa)
        
        NMDA receptor [plasma membrane] (Sus scrofa)
        
        NR2 subunits [plasma membrane] (Sus scrofa)
        
        GRIN2B [plasma membrane] (Sus scrofa)
      - SALM1:NMDAR:PSD-95 [plasma membrane] (Sus scrofa)
        
        NMDAR:PSD-95 [plasma membrane] (Sus scrofa)
        
        NMDA receptor complex [plasma membrane] (Sus scrofa)
        
        NMDA receptor [plasma membrane] (Sus scrofa)
        
        NR2 subunits [plasma membrane] (Sus scrofa)
        
        GRIN2B [plasma membrane] (Sus scrofa)
- Transmission across Chemical Synapses (Sus scrofa)
  - Neurotransmitter receptors and postsynaptic signal transmission (Sus scrofa)
    - Activation of NMDA receptors and postsynaptic events (Sus scrofa)
      - Assembly and cell surface presentation of NMDA receptors (Sus scrofa)
        
        GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Sus scrofa)
        
        GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B:GRIN2D tri-heterotetramer [plasma membrane] (Sus scrofa)
        
        GRIN2B [plasma membrane] (Sus scrofa)
      - Unblocking of NMDA receptors, glutamate binding and activation (Sus scrofa)
        
        Ca2+ influx into the post-synaptic cell (Sus scrofa)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2 NMDA receptors [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B:GRIN2D tri-heterotetramer [plasma membrane] (Sus scrofa)
        
        GRIN2B [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B di-heterotetramer [plasma membrane] (Sus scrofa)
        
        GRIN2B [plasma membrane] (Sus scrofa)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Sus scrofa)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Sus scrofa)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B di-heterotetramer [plasma membrane] (Sus scrofa)
        
        GRIN2B [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B:GRIN2D tri-heterotetramer [plasma membrane] (Sus scrofa)
        
        GRIN2B [plasma membrane] (Sus scrofa)

Signal Transduction (Sus scrofa)

- MAPK family signaling cascades (Sus scrofa)
  - MAPK1/MAPK3 signaling (Sus scrofa)
    - RAF/MAP kinase cascade (Sus scrofa)
      - RAS GEFs promote RAS nucleotide exchange (Sus scrofa)
        
        RAS GEFs [plasma membrane] (Sus scrofa)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Sus scrofa)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B di-heterotetramer [plasma membrane] (Sus scrofa)
        
        GRIN2B [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B:GRIN2D tri-heterotetramer [plasma membrane] (Sus scrofa)
        
        GRIN2B [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1SQ84

Reference Genes

BioGPS Gene:100626022

ENSEMBL:ENSSSCG00000000614.5

KEGG:ssc:100626022

Monarch:100626022

NCBI Gene:100626022

UCSC:F1SQ84

Reference Transcript

Other Identifiers

100626022

GO:0004972

GO:0005216

GO:0005789

GO:0005886

GO:0006811

GO:0007268

GO:0015276

GO:0016020

GO:0016594

GO:0017146

GO:0019722

GO:0022849

GO:0034220

GO:0035235

GO:0035249

GO:0038023

GO:0042391

GO:0045202

GO:0045211

GO:0045471

GO:0046872

GO:0055085

GO:0060079

GO:0060291

GO:0097553

GO:0098655

GO:0098839

GO:0099505

GO:0099507

GO:1904315

Participates

as a member of

NR2 subunits [plasma membrane] (Sus scrofa)

as a component of

Other forms of this molecule

phospho-p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane]

GRIN2B [endoplasmic reticulum membrane]

Inferred From

GRIN2B [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_020947976.1, XP_020947977.1, XP_020947974.1, XP_020947978.1, XP_020947975.1, XP_020947979.1, XP_020947973.1

ENSEMBL

ENSSSCP00000032116, ENSSSCT00000061900, ENSSSCG00000000614

VGNC

88684

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