Reactome | DSG2 [plasma membrane]

DSG2 [plasma membrane]

Stable Identifier

R-SSC-351896

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

DSG2, A0A287ATF2

Locations in the PathwayBrowser

Expand all

Developmental Biology (Sus scrofa)

- Keratinization (Sus scrofa)
  - Formation of the cornified envelope (Sus scrofa)
    - CASP14 cleaves filaggrin (Sus scrofa)
      - Late cornified envelope [plasma membrane] (Sus scrofa)
        
        Cornified envelope:CDSN [plasma membrane] (Sus scrofa)
        
        Cornified envelope [plasma membrane] (Sus scrofa)
        
        Early cornified envelope [plasma membrane] (Sus scrofa)
        
        FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Desmogelins [plasma membrane] (Sus scrofa)
        
        DSG2 [plasma membrane] (Sus scrofa)
      - Mature cornified envelope [plasma membrane] (Sus scrofa)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Sus scrofa)
        
        No FGN-Cornified envelope [plasma membrane] (Sus scrofa)
        
        No FGN-late cornified envelope [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Desmogelins [plasma membrane] (Sus scrofa)
        
        DSG2 [plasma membrane] (Sus scrofa)
    - CDSN binds the cornified envelope (Sus scrofa)
      - Cornified envelope [plasma membrane] (Sus scrofa)
        
        Early cornified envelope [plasma membrane] (Sus scrofa)
        
        FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Desmogelins [plasma membrane] (Sus scrofa)
        
        DSG2 [plasma membrane] (Sus scrofa)
      - Cornified envelope:CDSN [plasma membrane] (Sus scrofa)
        
        Cornified envelope [plasma membrane] (Sus scrofa)
        
        Early cornified envelope [plasma membrane] (Sus scrofa)
        
        FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Desmogelins [plasma membrane] (Sus scrofa)
        
        DSG2 [plasma membrane] (Sus scrofa)
    - Filaggrin binds Keratin tonofilament:Desmosome (Sus scrofa)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Desmogelins [plasma membrane] (Sus scrofa)
        
        DSG2 [plasma membrane] (Sus scrofa)
      - Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Desmogelins [plasma membrane] (Sus scrofa)
        
        DSG2 [plasma membrane] (Sus scrofa)
    - Fillagrin and keratin intermediate filaments polymerize forming a network (Sus scrofa)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Desmogelins [plasma membrane] (Sus scrofa)
        
        DSG2 [plasma membrane] (Sus scrofa)
      - FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Desmogelins [plasma membrane] (Sus scrofa)
        
        DSG2 [plasma membrane] (Sus scrofa)
    - Lamellar bodies bind the early cornified envelope (Sus scrofa)
      - Cornified envelope [plasma membrane] (Sus scrofa)
        
        Early cornified envelope [plasma membrane] (Sus scrofa)
        
        FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Desmogelins [plasma membrane] (Sus scrofa)
        
        DSG2 [plasma membrane] (Sus scrofa)
      - Early cornified envelope [plasma membrane] (Sus scrofa)
        
        FLG-Keratin filament network [plasma membrane] (Sus scrofa)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Desmogelins [plasma membrane] (Sus scrofa)
        
        DSG2 [plasma membrane] (Sus scrofa)
    - PERP binds desmosomes (Sus scrofa)
      - Desmosome [plasma membrane] (Sus scrofa)
        
        Desmogelins [plasma membrane] (Sus scrofa)
        
        DSG2 [plasma membrane] (Sus scrofa)
      - Desmosome:PERP [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Desmogelins [plasma membrane] (Sus scrofa)
        
        DSG2 [plasma membrane] (Sus scrofa)
    - Plasma membrane resorption (Sus scrofa)
      - Mature cornified envelope [plasma membrane] (Sus scrofa)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Sus scrofa)
        
        No FGN-Cornified envelope [plasma membrane] (Sus scrofa)
        
        No FGN-late cornified envelope [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Sus scrofa)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
        
        Desmosome [plasma membrane] (Sus scrofa)
        
        Desmogelins [plasma membrane] (Sus scrofa)
        
        DSG2 [plasma membrane] (Sus scrofa)
  - Keratin filaments bind cell-cell adhesion complexes (Sus scrofa)
    - Desmosome [plasma membrane] (Sus scrofa)
      - Desmogelins [plasma membrane] (Sus scrofa)
        
        DSG2 [plasma membrane] (Sus scrofa)
    - Keratin tonofilament:Desmosome [plasma membrane] (Sus scrofa)
      - Desmosome [plasma membrane] (Sus scrofa)
        
        Desmogelins [plasma membrane] (Sus scrofa)
        
        DSG2 [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287ATF2

Gene Names

DSG2

Reference Genes

ENSEMBL:ENSSSCG00000022739.4

UCSC:A0A287ATF2 DSG2

Other Identifiers

100625833

GO:0002934

GO:0003165

GO:0005509

GO:0005737

GO:0005886

GO:0007155

GO:0007156

GO:0009986

GO:0010719

GO:0014704

GO:0016020

GO:0030054

GO:0030057

GO:0030154

GO:0034330

GO:0043066

GO:0045602

GO:0045785

GO:0046872

GO:0048856

GO:0050839

GO:0060231

GO:0070161

GO:0072089

GO:0086073

GO:0086091

GO:0098609

GO:0098911

GO:0106015

GO:0150107

GO:1902459

GO:1903672

Ssc.26884.1.S1_at

Ssc.3584.1.S1_at

Ssc.3584.2.S1_at

Ssc.3584.3.S1_at

Participates

as a candidate of

as a member of

Desmogelins [plasma membrane] (Sus scrofa)

as an input of

Caspase-mediated cleavage of Desmoglein 2 (Sus scrofa)

Other forms of this molecule

DSG2 [cornified envelope]

DSG2 [plasma membrane]

Inferred From

DSG2 [plasma membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSSSCG00000022739, ENSSSCP00000047363, ENSSSCT00000051217

VGNC

87456

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