Reactome | C4A [extracellular region]

C4A [extracellular region]

Stable Identifier

R-SSC-2855053

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

extracellular region

Synonyms

dNQ-C4A(757-1446), A0A5G2QCL1

Locations in the PathwayBrowser

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Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - Complement cascade (Sus scrofa)
    - Activation of C3 and C5 (Sus scrofa)
      - Activation of C5 (Sus scrofa)
        
        C5 convertases [plasma membrane] (Sus scrofa)
        
        C4b:C2a:C3b [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b:C2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
      - Cleavage of C3 by C3 convertases (Sus scrofa)
        
        C3 convertases [plasma membrane] (Sus scrofa)
        
        C4b:C2a:C3b [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b:C2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
        
        Cell surface:C4b:C2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
      - Formation of classic pathway C5 convertase (Sus scrofa)
        
        C4b:C2a:C3b [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b:C2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
        
        Cell surface:C4b:C2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
    - Initial triggering of complement (Sus scrofa)
      - C4b binds to cell surface (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
      - Formation of Classical C3 convertase (C4b:C2a complex) (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
        
        Cell surface:C4b:C2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
    - Regulation of Complement cascade (Sus scrofa)
      - C3 convertases spontaneously dissociate (Sus scrofa)
        
        C3 convertases [plasma membrane] (Sus scrofa)
        
        C4b:C2a:C3b [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b:C2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
        
        Cell surface:C4b:C2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
        
        Cell surface:C4b:C2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
      - CD46 binds C4b (Sus scrofa)
        
        CD46:Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
      - CD55 (DAF) binds C3bBb, C4bC2a (Sus scrofa)
        
        C4bC2a, C3bBb [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b:C2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
        
        CD55:C3 convertase complexes [plasma membrane] (Sus scrofa)
        
        CD55:C4bC2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b:C2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
      - CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Sus scrofa)
        
        CD55:C3 convertase complexes [plasma membrane] (Sus scrofa)
        
        CD55:C4bC2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b:C2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
        
        CD55:C4b [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
      - CR1 binds C3bBb/C4bC2a (Sus scrofa)
        
        C4bC2a, C3bBb [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b:C2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
        
        CR1:C3bBb, C4bC2a complexes [plasma membrane] (Sus scrofa)
        
        CR1:C4bC2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b:C2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
      - Complement factor I binds to MCP, CR1:C4b, C3b (Sus scrofa)
        
        CD46, CR1:C4b:C3b complexes [plasma membrane] (Sus scrofa)
        
        CD46:Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
        
        CR1:C4b [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
        
        CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Sus scrofa)
        
        CD46, CR1:C4b:C3b complexes [plasma membrane] (Sus scrofa)
        
        CD46:Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
        
        CR1:C4b [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
      - Displacement of C2a/Bb by CR1 (Sus scrofa)
        
        CR1:C3bBb, C4bC2a complexes [plasma membrane] (Sus scrofa)
        
        CR1:C4bC2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b:C2a [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
        
        CR1:C4b [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
      - Factor I inactivates MCP/CR1-bound C4b/C3b (Sus scrofa)
        
        CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Sus scrofa)
        
        CD46, CR1:C4b:C3b complexes [plasma membrane] (Sus scrofa)
        
        CD46:Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
        
        CR1:C4b [plasma membrane] (Sus scrofa)
        
        Cell surface:C4b [plasma membrane] (Sus scrofa)
        
        C4b [extracellular region] (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)
      - Hydrolysis of internal thioester in C4b (Sus scrofa)
        
        deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)
        
        C4A [extracellular region] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2QCL1

Gene Names

C4A

Reference Genes

ENSEMBL:ENSSSCG00000001427.6

UCSC:A0A5G2QCL1 C4A

Other Identifiers

445467

GO:0002376

GO:0004866

GO:0005515

GO:0005576

GO:0005615

GO:0006954

GO:0006956

GO:0006958

GO:0030424

GO:0030425

GO:0042995

GO:0045087

GO:0045202

GO:0098542

GO:0098772

Ssc.17026.1.S1_at

Participates

as a component of

deamidated-Q1013-C4A-derived C4b [extracellular region] (Sus scrofa)

Other forms of this molecule

phospho-C4A [endoplasmic reticulum lumen]

C4A [endoplasmic reticulum lumen]

C4A [extracellular region]

C4A [plasma membrane]

C4A [extracellular region]

Inferred From

dNQ-C4B(757-1446) [extracellular region] (Homo sapiens)

dNQ-C4A(757-1446) [extracellular region] (Homo sapiens)

Modified Residues

Name

deamidated L-glutamine at 1013 (in Homo sapiens)

Coordinate

1013

PsiMod Name

deamidated L-glutamine

PsiMod Definition

A protein modification that effectively converts an L-glutamine residue to L-glutamic acid.

Cross References

ENSEMBL

ENSSSCG00000001427, ENSSSCT00000079853, ENSSSCP00000061845

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