Reactome | DNM2 [cytosol]

DNM2 [cytosol]

Stable Identifier

R-SSC-2213180

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

DNM2, A0A287B8X7

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - Clathrin-mediated endocytosis (Sus scrofa)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        DNM:GDP [cytosol] (Sus scrofa)
        
        Dynamin [cytosol] (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        DNM:GDP [cytosol] (Sus scrofa)
        
        Dynamin [cytosol] (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
    - BAR domain proteins recruit dynamin (Sus scrofa)
      - DNM:GTP [cytosol] (Sus scrofa)
        
        Dynamin [cytosol] (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        DNM:GTP [cytosol] (Sus scrofa)
        
        Dynamin [cytosol] (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        DNM:GDP [cytosol] (Sus scrofa)
        
        Dynamin [cytosol] (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        DNM:GDP [cytosol] (Sus scrofa)
        
        Dynamin [cytosol] (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)
      - Dynamin [cytosol] (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        DNM:GDP [cytosol] (Sus scrofa)
        
        Dynamin [cytosol] (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        DNM:GTP [cytosol] (Sus scrofa)
        
        Dynamin [cytosol] (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        DNM:GTP [cytosol] (Sus scrofa)
        
        Dynamin [cytosol] (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        DNM:GTP [cytosol] (Sus scrofa)
        
        Dynamin [cytosol] (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Sus scrofa)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        DNM:GDP [cytosol] (Sus scrofa)
        
        Dynamin [cytosol] (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        DNM:GDP [cytosol] (Sus scrofa)
        
        Dynamin [cytosol] (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
    - RAB5 and GAPVD1 bind AP-2 (Sus scrofa)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        DNM:GDP [cytosol] (Sus scrofa)
        
        Dynamin [cytosol] (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        DNM:GTP [cytosol] (Sus scrofa)
        
        Dynamin [cytosol] (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        DNM:GTP [cytosol] (Sus scrofa)
        
        Dynamin [cytosol] (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
  - trans-Golgi Network Vesicle Budding (Sus scrofa)
    - Golgi Associated Vesicle Biogenesis (Sus scrofa)
      - trans-Golgi Network Coat Assembly (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
      - trans-Golgi Network Vesicle Scission (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
    - Lysosome Vesicle Biogenesis (Sus scrofa)
      - trans-Golgi Network Lysosomal Vesicle Scission (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)
      - trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Sus scrofa)
        
        DNM2 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287B8X7

Gene Names

DNM2

Reference Genes

BioGPS Gene:100622538 DNM2

ENSEMBL:ENSSSCG00000013630.5

Monarch:100622538 DNM2

NCBI Gene:100622538 DNM2

UCSC:A0A287B8X7 DNM2

Reference Transcript

RefSeq:XM_021083804.1 DNM2

Other Identifiers

100622538

GO:0000166

GO:0001891

GO:0001931

GO:0002102

GO:0003924

GO:0005525

GO:0005546

GO:0005737

GO:0005768

GO:0005794

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0005905

GO:0005938

GO:0006897

GO:0006898

GO:0006909

GO:0006914

GO:0008017

GO:0008092

GO:0012505

GO:0014069

GO:0016020

GO:0016185

GO:0016192

GO:0016787

GO:0017124

GO:0030136

GO:0030496

GO:0030670

GO:0031410

GO:0031623

GO:0033572

GO:0042995

GO:0043005

GO:0043226

GO:0045202

GO:0045211

GO:0051258

GO:0055037

GO:0061024

GO:0061572

GO:0070161

GO:0072687

GO:0097749

GO:0098793

GO:0099050

GO:1903526

Ssc.16815.1.S1_at

Participates

as an output of

as an input of

as a member of

Dynamin [cytosol] (Sus scrofa)

Other forms of this molecule

DNM2 [Golgi membrane]

DNM2 [endocytic vesicle membrane]

DNM2 [lysosomal membrane]

DNM2 [plasma membrane]

Inferred From

DNM2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_020939463.1

ENSEMBL

ENSSSCG00000013630, ENSSSCT00000060743, ENSSSCP00000052945

VGNC

87381

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