Reactome | COL8A2 [extracellular region]

COL8A2 [extracellular region]

Stable Identifier

R-SSC-2192745

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-GalHyl-COL8A2, A0A287AHD4

Locations in the PathwayBrowser

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Extracellular matrix organization (Sus scrofa)

- Collagen formation (Sus scrofa)
  - Assembly of collagen fibrils and other multimeric structures (Sus scrofa)
    - Formation of collagen networks (Sus scrofa)
      - Collagen networks [extracellular region] (Sus scrofa)
        
        Collagen type VIII fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type VIII [extracellular region] (Sus scrofa)
        
        COL8A2 [extracellular region] (Sus scrofa)
      - Network forming tropocollagens [extracellular region] (Sus scrofa)
        
        Tropocollagen type VIII [extracellular region] (Sus scrofa)
        
        COL8A2 [extracellular region] (Sus scrofa)
  - Collagen biosynthesis and modifying enzymes (Sus scrofa)
    - Secretion of collagens (Sus scrofa)
      - Collagens and tropocollagens [extracellular region] (Sus scrofa)
        
        Non-fibrillar collagens [extracellular region] (Sus scrofa)
        
        Tropocollagen type VIII [extracellular region] (Sus scrofa)
        
        COL8A2 [extracellular region] (Sus scrofa)
- Degradation of the extracellular matrix (Sus scrofa)
  - Collagen degradation (Sus scrofa)
    - Collagen type VIII degradation by MMP1 (Sus scrofa)
      - Collagen type VIII fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type VIII [extracellular region] (Sus scrofa)
        
        COL8A2 [extracellular region] (Sus scrofa)
- Integrin cell surface interactions (Sus scrofa)
  - Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Sus scrofa)
    - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Sus scrofa)
      - Collagen type VIII fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type VIII [extracellular region] (Sus scrofa)
        
        COL8A2 [extracellular region] (Sus scrofa)
    - Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Sus scrofa)
      - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Sus scrofa)
        
        Collagen type VIII fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type VIII [extracellular region] (Sus scrofa)
        
        COL8A2 [extracellular region] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287AHD4

Gene Names

COL8A2

Reference Genes

BioGPS Gene:100525585 COL8A2

ENSEMBL:ENSSSCG00000033641.3

KEGG:ssc:100525585 COL8A2

Monarch:100525585 COL8A2

NCBI Gene:100525585 COL8A2

UCSC:A0A287AHD4 COL8A2

Reference Transcript

RefSeq:XM_021095925.1 COL8A2

Other Identifiers

100525585

GO:0001935

GO:0005198

GO:0005576

GO:0005581

GO:0030020

GO:0030312

GO:0031012

GO:0048593

Participates

as a component of

Tropocollagen type VIII [extracellular region] (Sus scrofa)

Other forms of this molecule

COL8A2 [endoplasmic reticulum lumen]

COL8A2 [extracellular region]

COL8A2 [endoplasmic reticulum lumen]

Inferred From

Collagen alpha-2(VIII) chains [extracellular region] (Homo sapiens)

3x4Hyp-3Hyp-GalHyl-COL8A2 [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

RefSeq

XP_020951584.1

ENSEMBL

ENSSSCT00000061866, ENSSSCP00000043314, ENSSSCG00000033641

VGNC

86881