Reactome | COL3A1 [extracellular region]

COL3A1 [extracellular region]

Stable Identifier

R-SSC-2127382

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-GalHyl-COL3A1, A0A286ZQ85

Locations in the PathwayBrowser

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Extracellular matrix organization (Sus scrofa)

- Collagen formation (Sus scrofa)
  - Assembly of collagen fibrils and other multimeric structures (Sus scrofa)
    - Formation of collagen fibres (Sus scrofa)
      - Collagen fibres [extracellular region] (Sus scrofa)
        
        Collagen type III fibre [extracellular region] (Sus scrofa)
        
        Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
      - Collagen fibrils [extracellular region] (Sus scrofa)
        
        Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
    - Formation of collagen fibrils (Sus scrofa)
      - Collagen fibrils [extracellular region] (Sus scrofa)
        
        Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
      - Tropocollagens [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
  - Collagen biosynthesis and modifying enzymes (Sus scrofa)
    - Removal of fibrillar collagen C-propeptides (Sus scrofa)
      - Tropocollagens [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
- Degradation of the extracellular matrix (Sus scrofa)
  - Collagen degradation (Sus scrofa)
    - Collagen type III degradation by MMP1,8,9,13 (Sus scrofa)
      - Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
    - Collagen type III degradation by MMP14 (Sus scrofa)
      - Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
    - Collagen type III degradation by MMP15 (Sus scrofa)
      - Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
- ECM proteoglycans (Sus scrofa)
  - DCN binds collagen I, II, III, VI fibrils (Sus scrofa)
    - Collagen type I, II, III, VI fibrils [extracellular region] (Sus scrofa)
      - Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
    - DCN:Collagen type I, II, III, VI fibrils [extracellular region] (Sus scrofa)
      - Collagen type I, II, III, VI fibrils [extracellular region] (Sus scrofa)
        
        Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
  - VTN binds collagens II, III and V (Sus scrofa)
    - Collagen types II, III, V [extracellular region] (Sus scrofa)
      - Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
    - VTN:Collagen types II,III,V [extracellular region] (Sus scrofa)
      - Collagen types II, III, V [extracellular region] (Sus scrofa)
        
        Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
- Fibronectin matrix formation (Sus scrofa)
  - FN1 binds Collagen types I-V, VII (Sus scrofa)
    - Collagen types I-V, VII [extracellular region] (Sus scrofa)
      - Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
    - FN1(32-2386):Collagen types I-V, VII [extracellular region] (Sus scrofa)
      - Collagen types I-V, VII [extracellular region] (Sus scrofa)
        
        Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
- Integrin cell surface interactions (Sus scrofa)
  - Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Sus scrofa)
    - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Sus scrofa)
      - Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
    - Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Sus scrofa)
      - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Sus scrofa)
        
        Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
- Non-integrin membrane-ECM interactions (Sus scrofa)
  - DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Sus scrofa)
    - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Sus scrofa)
      - Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
    - DDR1 dimer:Collagen type I, II, III, IV, V, XI fibrils [plasma membrane] (Sus scrofa)
      - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Sus scrofa)
        
        Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
  - DDR2 binds collagen type I, II, III, V, X fibrils (Sus scrofa)
    - Collagen type I, II, III, V, X fibrils [extracellular region] (Sus scrofa)
      - Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
    - DDR2 dimer:Collagen type I, II, III, V, X fibrils [plasma membrane] (Sus scrofa)
      - Collagen type I, II, III, V, X fibrils [extracellular region] (Sus scrofa)
        
        Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by PDGF (Sus scrofa)
    - PDGF binds to extracellular matrix proteins (Sus scrofa)
      - Extracellular matrix ligands [extracellular region] (Sus scrofa)
        
        Collagens [extracellular region] (Sus scrofa)
        
        Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)
      - PDGF A and B chains:ECM complex [extracellular region] (Sus scrofa)
        
        Extracellular matrix ligands [extracellular region] (Sus scrofa)
        
        Collagens [extracellular region] (Sus scrofa)
        
        Collagen type III fibril [extracellular region] (Sus scrofa)
        
        Tropocollagen type III [extracellular region] (Sus scrofa)
        
        COL3A1 [extracellular region] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A286ZQ85

Gene Names

COL3A1

Reference Genes

ENSEMBL:ENSSSCG00000016034.5

UCSC:A0A286ZQ85 COL3A1

Other Identifiers

100152001

GO:0002020

GO:0005178

GO:0005198

GO:0005201

GO:0005515

GO:0005576

GO:0005581

GO:0005586

GO:0005615

GO:0007155

GO:0007160

GO:0007179

GO:0007229

GO:0007507

GO:0009314

GO:0030020

GO:0030198

GO:0030199

GO:0030312

GO:0031012

GO:0034097

GO:0042060

GO:0043588

GO:0046872

GO:0048407

GO:0048856

GO:0050777

GO:0097435

Ssc.11302.1.S1_at

Ssc.11302.1.S2_at

Participates

as a component of

Tropocollagen type III [extracellular region] (Sus scrofa)

Other forms of this molecule

COL3A1 [endoplasmic reticulum lumen]

COL3A1 [extracellular region]

Inferred From

Collagen alpha-1(III) chains [extracellular region] (Homo sapiens)

3x4Hyp-3Hyp-GalHyl-COL3A1 [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

ENSEMBL

ENSSSCG00000016034, ENSSSCT00000056782, ENSSSCP00000033771

VGNC

95979

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