Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
GRB2 [plasma membrane]
Stable Identifier
R-SSC-202993
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
plasma membrane
Synonyms
GRB2-1, B6E241
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Signaling by the B Cell Receptor (BCR) (Sus scrofa)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Sus scrofa)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Sus scrofa)
BLNK (SLP-65) Signalosome [plasma membrane] (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Sus scrofa)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Sus scrofa)
GRB2 [plasma membrane] (Sus scrofa)
BTK binds BTK inhibitors (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Sus scrofa)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Sus scrofa)
GRB2 [plasma membrane] (Sus scrofa)
BTK:BTK inhibitors [plasma membrane] (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Sus scrofa)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Sus scrofa)
GRB2 [plasma membrane] (Sus scrofa)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)
CD19 Signalosome [plasma membrane] (Sus scrofa)
GRB2 [plasma membrane] (Sus scrofa)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Sus scrofa)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Sus scrofa)
GRB2 [plasma membrane] (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Sus scrofa)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Sus scrofa)
GRB2 [plasma membrane] (Sus scrofa)
p-6Y-SYK phosphorylates BLNK (SLP65) (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Sus scrofa)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Sus scrofa)
GRB2 [plasma membrane] (Sus scrofa)
p-CD19:VAV binds PI3K and GRB2 (Sus scrofa)
CD19 Signalosome [plasma membrane] (Sus scrofa)
GRB2 [plasma membrane] (Sus scrofa)
Signal Transduction (Sus scrofa)
Intracellular signaling by second messengers (Sus scrofa)
PIP3 activates AKT signaling (Sus scrofa)
Negative regulation of the PI3K/AKT network (Sus scrofa)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
Activator:PI3K [plasma membrane] (Sus scrofa)
CD19 Signalosome [plasma membrane] (Sus scrofa)
GRB2 [plasma membrane] (Sus scrofa)
PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
Activator:PI3K [plasma membrane] (Sus scrofa)
CD19 Signalosome [plasma membrane] (Sus scrofa)
GRB2 [plasma membrane] (Sus scrofa)
External Reference Information
External Reference
UniProt:B6E241
Gene Names
GRB2
Reference Genes
BioGPS Gene:100192436 GRB2
ENSEMBL:ENSSSCG00000017206.5
KEGG:ssc:100192436 GRB2
Monarch:100192436 GRB2
NCBI Gene:100192436 GRB2
UCSC:B6E241 GRB2
Reference Transcript
RefSeq:NM_001137628.1 GRB2
Other Identifiers
100192436
GO:0001784
GO:0002376
GO:0005068
GO:0005091
GO:0005154
GO:0005168
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005794
GO:0005813
GO:0005815
GO:0005829
GO:0005886
GO:0005911
GO:0005938
GO:0007165
GO:0007173
GO:0007265
GO:0008180
GO:0008286
GO:0008543
GO:0012506
GO:0014044
GO:0016020
GO:0016192
GO:0017124
GO:0019901
GO:0019903
GO:0019904
GO:0030036
GO:0030154
GO:0030674
GO:0030838
GO:0031295
GO:0031623
GO:0035987
GO:0042059
GO:0042110
GO:0042267
GO:0042552
GO:0042770
GO:0042802
GO:0043408
GO:0043560
GO:0045953
GO:0046875
GO:0048009
GO:0048646
GO:0048856
GO:0050853
GO:0060090
GO:0060670
GO:0070436
GO:0071479
GO:2000379
Ssc.19334.1.S1_at
Ssc.27313.3.S1_at
Participates
as a component of
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Sus scrofa)
CD19 Signalosome [plasma membrane] (Sus scrofa)
Other forms of this molecule
GRB2 [cytosol]
Inferred From
GRB2-1 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_001131100.1
ENSEMBL
ENSSSCP00000018229
,
ENSSSCG00000017206
,
ENSSSCT00000018731
VGNC
88663
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text