Reactome | FAM83F [cytosol]

FAM83F [cytosol]

Stable Identifier

R-SSC-202367

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

GRAP2, F1SRA1

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Regulation of T cell activation by CD28 family (Sus scrofa)
    - Co-stimulation by CD28 (Sus scrofa)
      - Gads binds CD28 (Sus scrofa)
        
        CD28:GRAP2 [plasma membrane] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
  - TCR signaling (Sus scrofa)
    - Generation of second messenger molecules (Sus scrofa)
      - Disassociation of PLC-gamma1 from SLP-76 (Sus scrofa)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Sus scrofa)
        
        GADS:p-5Y-LAT [plasma membrane] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Sus scrofa)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Sus scrofa)
        
        GADS:p-5Y-LAT [plasma membrane] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Phosphorylation of PLC-gamma1 (Sus scrofa)
        
        PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Sus scrofa)
        
        PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Sus scrofa)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Sus scrofa)
        
        GADS:p-5Y-LAT [plasma membrane] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        Phosphorylated PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Sus scrofa)
        
        phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Sus scrofa)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Sus scrofa)
        
        GADS:p-5Y-LAT [plasma membrane] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Sus scrofa)
        
        ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Sus scrofa)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Sus scrofa)
        
        GADS:p-5Y-LAT [plasma membrane] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Phosphorylation of SLP-76 (Sus scrofa)
        
        SLP-76 bound to Gads:LAT [plasma membrane] (Sus scrofa)
        
        GADS:p-5Y-LAT [plasma membrane] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Sus scrofa)
        
        GADS:p-5Y-LAT [plasma membrane] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Recruitment of Gads to LAT (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        GADS:p-5Y-LAT [plasma membrane] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Recruitment of ITK to SLP-76 (Sus scrofa)
        
        ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Sus scrofa)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Sus scrofa)
        
        GADS:p-5Y-LAT [plasma membrane] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Sus scrofa)
        
        GADS:p-5Y-LAT [plasma membrane] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Recruitment of PLC-gamma1 to SLP-76 (Sus scrofa)
        
        PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Sus scrofa)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Sus scrofa)
        
        GADS:p-5Y-LAT [plasma membrane] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Sus scrofa)
        
        GADS:p-5Y-LAT [plasma membrane] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Recruitment of SLP-76 to Gads (Sus scrofa)
        
        GADS:p-5Y-LAT [plasma membrane] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        SLP-76 bound to Gads:LAT [plasma membrane] (Sus scrofa)
        
        GADS:p-5Y-LAT [plasma membrane] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
- Cytokine Signaling in Immune system (Sus scrofa)
  - FLT3 Signaling (Sus scrofa)
    - Active FLT3 binds to GRAP2 (Sus scrofa)
      - FAM83F [cytosol] (Sus scrofa)
      - active FLT3:GRAP2 [plasma membrane] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - DAP12 interactions (Sus scrofa)
    - DAP12 signaling (Sus scrofa)
      - Activation of RAC1 by VAV2/3 (Sus scrofa)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Sus scrofa)
        
        GADS:SLP76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Sus scrofa)
        
        GADS:SLP76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Sus scrofa)
        
        GADS:SLP76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Sus scrofa)
        
        GADS:SLP76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Recruitment of VAV and BTK to p-SLP-76 (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Release of p-PLCG1 (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
  - Fc epsilon receptor (FCERI) signaling (Sus scrofa)
    - FCERI mediated Ca+2 mobilization (Sus scrofa)
      - Autophosphorylation of BTK/ITK (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Hydrolysis of PIP2 by PLCG (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Phosphorylation of TEC kinases by p-SYK (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
    - FCERI mediated MAPK activation (Sus scrofa)
      - Activation of RAC1 by VAV (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Autophosphorylation of PAK (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Phosphorylation and activation of VAV (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Phosphorylation of SLP-76 by p-SYK (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Sus scrofa)
        
        GADS:SLP76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Sus scrofa)
        
        GADS:SLP76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Sus scrofa)
        
        GADS:SLP76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Recruitment of PAK to the membrane by binding active RAC1 (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Sus scrofa)
        
        GADS:SLP76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Sus scrofa)
        
        GADS:SLP76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
      - Recruitment of VAV to p-SLP-76 (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Sus scrofa)
        
        FAM83F [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1SRA1

Gene Names

FAM83F

Reference Genes

BioGPS Gene:100516438 FAM83F

ENSEMBL:ENSSSCG00005007151.1

Monarch:100516438 FAM83F

NCBI Gene:100516438 FAM83F

UCSC:F1SRA1 FAM83F

Reference Transcript

RefSeq:XM_013997505.2 FAM83F

Other Identifiers

100516438

GO:0001784

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0007165

GO:0043408

Participates

as an input of

as a component of

as a member of

Adapter proteins [cytosol] (Sus scrofa)

Inferred From

GRAP2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_013852959.1

ENSEMBL

ENSSSCT00000000086, ENSSSCP00000000085, ENSSSCG00000000080

VGNC

87991

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