Reactome | WIPF1 [cytosol]

WIPF1 [cytosol]

Stable Identifier

R-SSC-201874

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

WIPF1, A0A287AFT4

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
    - Regulation of actin dynamics for phagocytic cup formation (Sus scrofa)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Sus scrofa)
        
        Mother filament:branching complex [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Sus scrofa)
        
        WIPF1 [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Sus scrofa)
        
        WIPF1 [cytosol] (Sus scrofa)
      - Detachment of WASP/WAVE (Sus scrofa)
        
        Mother filament:branching complex [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Sus scrofa)
        
        WIPF1 [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Sus scrofa)
        
        WIPF1 [cytosol] (Sus scrofa)
      - WIP binds WASP,N-WASP, activating them (Sus scrofa)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Sus scrofa)
        
        WIPF1 [cytosol] (Sus scrofa)
        
        WIPF1 [cytosol] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
  - Signaling by Rho GTPases (Sus scrofa)
    - RHO GTPase Effectors (Sus scrofa)
      - RHO GTPases Activate WASPs and WAVEs (Sus scrofa)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Sus scrofa)
        
        Mother filament:branching complex [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Sus scrofa)
        
        WIPF1 [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Sus scrofa)
        
        WIPF1 [cytosol] (Sus scrofa)
        
        Detachment of WASP/WAVE (Sus scrofa)
        
        Mother filament:branching complex [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Sus scrofa)
        
        WIPF1 [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Sus scrofa)
        
        WIPF1 [cytosol] (Sus scrofa)
        
        WIP binds WASP,N-WASP, activating them (Sus scrofa)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Sus scrofa)
        
        WIPF1 [cytosol] (Sus scrofa)
        
        WIPF1 [cytosol] (Sus scrofa)
    - RHO GTPase cycle (Sus scrofa)
      - CDC42 GTPase cycle (Sus scrofa)
        
        CDC42 binds effectors at the plasma membrane (Sus scrofa)
        
        CDC42 effectors [cytosol] (Sus scrofa)
        
        WIP:WASP complex [cytosol] (Sus scrofa)
        
        WIPF1 [cytosol] (Sus scrofa)
        
        CDC42:GTP:CDC42 effectors [plasma membrane] (Sus scrofa)
        
        CDC42 effectors [cytosol] (Sus scrofa)
        
        WIP:WASP complex [cytosol] (Sus scrofa)
        
        WIPF1 [cytosol] (Sus scrofa)
      - RAC1 GTPase cycle (Sus scrofa)
        
        RAC1 binds effectors at the plasma membrane (Sus scrofa)
        
        RAC1 effectors [cytosol] (Sus scrofa)
        
        WIP:WASP complex [cytosol] (Sus scrofa)
        
        WIPF1 [cytosol] (Sus scrofa)
        
        RAC1:GTP:RAC1 effectors [plasma membrane] (Sus scrofa)
        
        RAC1 effectors [cytosol] (Sus scrofa)
        
        WIP:WASP complex [cytosol] (Sus scrofa)
        
        WIPF1 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287AFT4

Gene Names

WIPF1

Reference Genes

ENSEMBL:ENSSSCG00000027348.4

UCSC:A0A287AFT4 WIPF1

Other Identifiers

100154822

GO:0001726

GO:0003779

GO:0005737

GO:0005856

GO:0005884

GO:0008092

GO:0015629

GO:0030029

GO:0030048

GO:0031410

GO:0042995

Ssc.10160.1.A1_at

Participates

as a component of

as an input of

WIP binds WASP,N-WASP, activating them (Sus scrofa)

Inferred From

WIP family proteins [cytosol] (Homo sapiens)

WIPF1 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSSSCT00000039472, ENSSSCP00000042839, ENSSSCG00000027348