Reactome | ACTB [cytosol]

ACTB [cytosol]

Stable Identifier

R-SSC-201861

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

ACTB, Q6QAQ1

Locations in the PathwayBrowser

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Cell-Cell communication (Sus scrofa)

- Cell junction organization (Sus scrofa)
  - Cell-cell junction organization (Sus scrofa)
    - Adherens junctions interactions (Sus scrofa)
      - Activation of STAT3 by cadherin engagement (Sus scrofa)
        
        CDH1 forms homotypic trans-dimers (Sus scrofa)
        
        Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Sus scrofa)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        Homotypic CDH1 trans-dimer cluster [plasma membrane] (Sus scrofa)
        
        Homotypic CDH1 trans-dimer [plasma membrane] (Sus scrofa)
        
        Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane] (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        trans-homotypic CDH1 cluster:F-actin:VCL [plasma membrane] (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        CDH1-associated CTNNA1 binds F-actin (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        CDH1-associated CTNNA1 binds VCL (Sus scrofa)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Sus scrofa)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination (Sus scrofa)
        
        Engaged CDH1,(CDH11) [plasma membrane] (Sus scrofa)
        
        Homotypic CDH1 trans-dimer cluster [plasma membrane] (Sus scrofa)
        
        Homotypic CDH1 trans-dimer [plasma membrane] (Sus scrofa)
        
        Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane] (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
      - Regulation of Homotypic Cell-Cell Adhesion (Sus scrofa)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Sus scrofa)
        
        Regulation of CDH1 Expression and Function (Sus scrofa)
        
        Regulation of CDH1 Function (Sus scrofa)
        
        CDH1 forms homotypic trans-dimers (Sus scrofa)
        
        Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Sus scrofa)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        Homotypic CDH1 trans-dimer cluster [plasma membrane] (Sus scrofa)
        
        Homotypic CDH1 trans-dimer [plasma membrane] (Sus scrofa)
        
        Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane] (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        trans-homotypic CDH1 cluster:F-actin:VCL [plasma membrane] (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        CDH1-associated CTNNA1 binds F-actin (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        CDH1-associated CTNNA1 binds VCL (Sus scrofa)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Sus scrofa)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
  - Cell-extracellular matrix interactions (Sus scrofa)
    - MigFilin associates with Filamin and F-actin (Sus scrofa)
      - F-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
      - Migfilin:Filamin A:F-actin [cytosol] (Sus scrofa)
        
        F-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)

Developmental Biology (Sus scrofa)

- Nervous system development (Sus scrofa)
  - Axon guidance (Sus scrofa)
    - EPH-Ephrin signaling (Sus scrofa)
      - EPHB-mediated forward signaling (Sus scrofa)
        
        N-WASP binds ARP2/3 and G-actin (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)

Extracellular matrix organization (Sus scrofa)

- Non-integrin membrane-ECM interactions (Sus scrofa)
  - Formation of the dystrophin-glycoprotein complex (DGC) (Sus scrofa)
    - DGC complex binds AGRN and HSPG2 (Sus scrofa)
      - DGC complex:laminins:F-actin [plasma membrane] (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
      - DGC complex:laminins:F-actin:AGRN,HSPG2 [plasma membrane] (Sus scrofa)
        
        DGC complex:laminins:F-actin [plasma membrane] (Sus scrofa)
        
        F-actin (all) [cytosol] (Sus scrofa)
        
        actins:ATP [cytosol] (Sus scrofa)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)

Hemostasis (Sus scrofa)

- Platelet activation, signaling and aggregation (Sus scrofa)
  - Response to elevated platelet cytosolic Ca2+ (Sus scrofa)
    - Platelet degranulation (Sus scrofa)
      - Release of platelet cytosolic components (Sus scrofa)
        
        Platelet releasate cytosolic proteins [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:Q6QAQ1

Gene Names

ACTB

Reference Genes

BioGPS Gene:414396 ACTB

ENSEMBL:ENSSSCG00000007585

KEGG:ssc:414396 ACTB

Monarch:414396 ACTB

NCBI Gene:414396 ACTB

UCSC:Q6QAQ1 ACTB

Reference Transcript

Other Identifiers

414396

GO:0000786

GO:0001738

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005903

GO:0005911

GO:0005912

GO:0007163

GO:0008092

GO:0015629

GO:0016787

GO:0016887

GO:0019894

GO:0019901

GO:0030027

GO:0030235

GO:0030863

GO:0030957

GO:0032991

GO:0034330

GO:0034333

GO:0035267

GO:0036464

GO:0042802

GO:0043226

GO:0043296

GO:0044305

GO:0045176

GO:0048870

GO:0050998

GO:0051621

GO:0051726

GO:0070160

GO:0071896

GO:0072749

GO:0098685

GO:0098772

GO:0098871

GO:0098973

GO:0098978

GO:0141108

GO:0150111

GO:1900242

GO:1903076

GO:1905168

GO:1990904

Ssc.4003.1.S1_at

Participates

as a candidate of

RHOF effectors [cytosol] (Sus scrofa)

as a member of

as a component of

Other forms of this molecule

ACTB [cytosol]

ACTB [extracellular region]

ACTB [nucleoplasm]

ACTB [lysosomal membrane]

ACTB [plasma membrane]

Inferred From

POTEKP [cytosol] (Homo sapiens)

ACTB, ACTG1 [cytosol] (Homo sapiens)

ACTB [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSSSCG00000007585, ENSSSCT00000042531, ENSSSCP00000035521

VGNC

96915

PDB

6F3A, 8IAH, 8IAI, 6F38, 9I2B, 5AFU, 7Z8M, 6F1T, 7Z8F, 8P94, 6ZNO, 6ZNN, 6ZO4, 6ZNL, 6ZNM, 9DGV, 8PTK, 9DGT, 5ADX, 9DGU, 9DGR, 9DGS, 8IB2

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