Reactome | PSEN2 [plasma membrane]

PSEN2 [plasma membrane]

Stable Identifier

R-SSC-201599

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

PSEN2(1-297), A0A2C9F398

Locations in the PathwayBrowser

Expand all

Developmental Biology (Sus scrofa)

- Nervous system development (Sus scrofa)
  - Axon guidance (Sus scrofa)
    - EPH-Ephrin signaling (Sus scrofa)
      - EPH-ephrin mediated repulsion of cells (Sus scrofa)
        
        gamma-secretase cleaves EPHB2 (Sus scrofa)
        
        gamma-secretase complex [plasma membrane] (Sus scrofa)
        
        Presenilin [plasma membrane] (Sus scrofa)
        
        PSEN2 [plasma membrane] (Sus scrofa)
        
        Homologues of PSEN2(1-297) [plasma membrane] (Sus scrofa)
        
        PSEN2 [plasma membrane] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Death Receptor Signaling (Sus scrofa)
  - p75 NTR receptor-mediated signalling (Sus scrofa)
    - Regulated proteolysis of p75NTR (Sus scrofa)
      - gamma-secretase cleaves the p75NTR transmembrane domain (Sus scrofa)
        
        gamma-secretase complex [plasma membrane] (Sus scrofa)
        
        Presenilin [plasma membrane] (Sus scrofa)
        
        PSEN2 [plasma membrane] (Sus scrofa)
        
        Homologues of PSEN2(1-297) [plasma membrane] (Sus scrofa)
        
        PSEN2 [plasma membrane] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by ERBB4 (Sus scrofa)
    - Nuclear signaling by ERBB4 (Sus scrofa)
      - Cleavage of ERBB4m80 by gamma-scretase complex (Sus scrofa)
        
        gamma-secretase complex [plasma membrane] (Sus scrofa)
        
        Presenilin [plasma membrane] (Sus scrofa)
        
        PSEN2 [plasma membrane] (Sus scrofa)
        
        Homologues of PSEN2(1-297) [plasma membrane] (Sus scrofa)
        
        PSEN2 [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A2C9F398

Gene Names

PSEN2

Reference Genes

ENSEMBL:ENSSSCG00000010860.5

Other Identifiers

780410

GO:0000139

GO:0000776

GO:0003824

GO:0004190

GO:0005634

GO:0005635

GO:0005637

GO:0005694

GO:0005783

GO:0005789

GO:0005794

GO:0005813

GO:0005815

GO:0005856

GO:0005886

GO:0006508

GO:0006509

GO:0007219

GO:0008233

GO:0016020

GO:0016485

GO:0016787

GO:0023052

GO:0032991

GO:0034205

GO:0035556

GO:0042500

GO:0042987

GO:0043226

GO:0043229

GO:0051604

GO:0055085

GO:0070765

GO:0110097

GO:0140096

GO:1990456

Ssc.19400.1.S1_at

Ssc.24175.1.A1_at

Participates

as a member of

Homologues of PSEN2(1-297) [plasma membrane] (Sus scrofa)

Other forms of this molecule

PSEN2 [plasma membrane]

Inferred From

PSEN2(1-297) [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000143801

Ensembl

ENSSSCG00000010860, ENSSSCT00000011882, ENSSSCP00000011578

VGNC

96508

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