Reactome | NCKAP1 [cytosol]

NCKAP1 [cytosol]

Stable Identifier

R-SSC-200979

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

NCKAP1, A0A287AJY4

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
    - Regulation of actin dynamics for phagocytic cup formation (Sus scrofa)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Sus scrofa)
        
        Mother filament:branching complex [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        p-Y,S,T-WRC [cytosol] (Sus scrofa)
        
        NCKAP1 [cytosol] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        p-Y-WRC [cytosol] (Sus scrofa)
        
        NCKAP1 [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        p-Y,S,T-WRC [cytosol] (Sus scrofa)
        
        NCKAP1 [cytosol] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        p-Y-WRC [cytosol] (Sus scrofa)
        
        NCKAP1 [cytosol] (Sus scrofa)
      - ABL phosphorylates WAVEs (Sus scrofa)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        WAVE Regulatory Complex [cytosol] (Sus scrofa)
        
        NCKAP1 [cytosol] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        p-Y-WRC [cytosol] (Sus scrofa)
        
        NCKAP1 [cytosol] (Sus scrofa)
      - Detachment of WASP/WAVE (Sus scrofa)
        
        Mother filament:branching complex [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        p-Y,S,T-WRC [cytosol] (Sus scrofa)
        
        NCKAP1 [cytosol] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        p-Y-WRC [cytosol] (Sus scrofa)
        
        NCKAP1 [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        p-Y,S,T-WRC [cytosol] (Sus scrofa)
        
        NCKAP1 [cytosol] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        p-Y-WRC [cytosol] (Sus scrofa)
        
        NCKAP1 [cytosol] (Sus scrofa)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Sus scrofa)
        
        WAVE Regulatory Complex [cytosol] (Sus scrofa)
        
        NCKAP1 [cytosol] (Sus scrofa)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        WAVE Regulatory Complex [cytosol] (Sus scrofa)
        
        NCKAP1 [cytosol] (Sus scrofa)
      - p-ERK phosphorylates WAVEs and ABI (Sus scrofa)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Sus scrofa)
        
        p-Y,S,T-WRC [cytosol] (Sus scrofa)
        
        NCKAP1 [cytosol] (Sus scrofa)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Sus scrofa)
        
        p-Y-WRC [cytosol] (Sus scrofa)
        
        NCKAP1 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287AJY4

Gene Names

NCKAP1

Reference Genes

BioGPS Gene:100158033 NCKAP1

ENSEMBL:ENSSSCG00000016019

ENSEMBL:ENSSSCG00000016019.4 NCKAP1

Monarch:100158033 NCKAP1

NCBI Gene:100158033 NCKAP1

Reference Transcript

RefSeq:XM_003359582.3 NCKAP1

Other Identifiers

100158033

GO:0000902

GO:0005622

GO:0005737

GO:0007010

GO:0010592

GO:0016477

GO:0016601

GO:0023052

GO:0030031

GO:0030154

GO:0030866

GO:0031209

GO:0031267

GO:0032991

GO:0048812

GO:0048856

GO:0048870

GO:2000601

Ssc.29835.1.A1_at

Ssc.9244.1.A1_at

Participates

as a candidate of

as a component of

Inferred From

NCKAP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_003359630.1

OpenTargets

ENSG00000061676

Ensembl

ENSSSCT00000046639, ENSSSCP00000044211, ENSSSCG00000016019

VGNC

96432

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