Reactome | ELMO1 [cytosol]

ELMO1 [cytosol]

Stable Identifier

R-SSC-200932

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

ELMO1, A0A4X1W6I3

Locations in the PathwayBrowser

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Cell-Cell communication (Sus scrofa)

- Cell junction organization (Sus scrofa)
  - Cell-cell junction organization (Sus scrofa)
    - Adherens junctions interactions (Sus scrofa)
      - Activation of STAT3 by cadherin engagement (Sus scrofa)
        
        SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) (Sus scrofa)
        
        SRC promotes RAC1 and CDC42 activation by phosphorylating RAC1 and CDC42 GEFs (Sus scrofa)
        
        SRC targeted RAC1/CDC42 GEFs [cytosol] (Sus scrofa)
        
        SRC-targeted RAC1 GEFs [cytosol] (Sus scrofa)
        
        DOCK1:ELMO1 [cytosol] (Sus scrofa)
        
        ELMO1 [cytosol] (Sus scrofa)

Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
    - Regulation of actin dynamics for phagocytic cup formation (Sus scrofa)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1 [cytosol] (Sus scrofa)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1 [cytosol] (Sus scrofa)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1 [cytosol] (Sus scrofa)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1 [cytosol] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Non-Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by PTK6 (Sus scrofa)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Sus scrofa)
      - Activation of RAC1 by the PXN:CRK complex (Sus scrofa)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1 [cytosol] (Sus scrofa)
      - Phosphorylated PXN recruits the CRK complex (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1 [cytosol] (Sus scrofa)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1 [cytosol] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by VEGF (Sus scrofa)
    - VEGFA-VEGFR2 Pathway (Sus scrofa)
      - DOCK180:ELMO binds CRK (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1 [cytosol] (Sus scrofa)
        
        DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1 [cytosol] (Sus scrofa)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1 [cytosol] (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A4X1W6I3

Gene Names

ELMO1

Reference Genes

ENSEMBL:ENSSSCG00000058042.1

UCSC:A0A4X1W6I3 ELMO1

Other Identifiers

100522109

GO:0005085

GO:0005737

GO:0005886

GO:0006909

GO:0006911

GO:0006915

GO:0007015

GO:0016020

GO:0016192

GO:0016601

GO:0017124

GO:0030036

GO:0032045

GO:0048870

GO:0061024

Ssc.5648.1.A1_at

Participates

as a component of

DOCK1:ELMO1 [cytosol] (Sus scrofa)

as a member of

ELMO1,ELMO2 [cytosol] (Sus scrofa)

Other forms of this molecule

phospho-ELMO1 [cytosol]

Inferred From

ELMO1 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSSSCT00000095013, ENSSSCP00000077355, ENSSSCG00000058042