Reactome | RPS6KA1 [nucleoplasm]

RPS6KA1 [nucleoplasm]

Stable Identifier

R-SSC-199860

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

A0A287BHE2

Locations in the PathwayBrowser

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Cellular responses to stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Cellular Senescence (Sus scrofa)
    - Senescence-Associated Secretory Phenotype (SASP) (Sus scrofa)
      - ERK1/2/5 activate RSK1/2/3 (Sus scrofa)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Sus scrofa)
        
        RPS6KA1 [nucleoplasm] (Sus scrofa)

Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-17 signaling (Sus scrofa)
      - MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERK1/2/5 activate RSK1/2/3 (Sus scrofa)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Sus scrofa)
        
        RPS6KA1 [nucleoplasm] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - Toll-like Receptor Cascades (Sus scrofa)
    - Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERK1/2/5 activate RSK1/2/3 (Sus scrofa)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Sus scrofa)
        
        RPS6KA1 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
      - Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERK1/2/5 activate RSK1/2/3 (Sus scrofa)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Sus scrofa)
        
        RPS6KA1 [nucleoplasm] (Sus scrofa)
      - Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERK1/2/5 activate RSK1/2/3 (Sus scrofa)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Sus scrofa)
        
        RPS6KA1 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
      - MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERK1/2/5 activate RSK1/2/3 (Sus scrofa)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Sus scrofa)
        
        RPS6KA1 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
      - MyD88-independent TLR4 cascade (Sus scrofa)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERK1/2/5 activate RSK1/2/3 (Sus scrofa)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Sus scrofa)
        
        RPS6KA1 [nucleoplasm] (Sus scrofa)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERK1/2/5 activate RSK1/2/3 (Sus scrofa)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Sus scrofa)
        
        RPS6KA1 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERK1/2/5 activate RSK1/2/3 (Sus scrofa)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Sus scrofa)
        
        RPS6KA1 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERK1/2/5 activate RSK1/2/3 (Sus scrofa)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Sus scrofa)
        
        RPS6KA1 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERK1/2/5 activate RSK1/2/3 (Sus scrofa)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Sus scrofa)
        
        RPS6KA1 [nucleoplasm] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by GPCR (Sus scrofa)
  - GPCR downstream signalling (Sus scrofa)
    - G alpha (q) signalling events (Sus scrofa)
      - Gastrin-CREB signalling pathway via PKC and MAPK (Sus scrofa)
        
        ERK1/2/5 activate RSK1/2/3 (Sus scrofa)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Sus scrofa)
        
        RPS6KA1 [nucleoplasm] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by NTRKs (Sus scrofa)
    - Signaling by NTRK1 (TRKA) (Sus scrofa)
      - Nuclear Events (kinase and transcription factor activation) (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERK1/2/5 activate RSK1/2/3 (Sus scrofa)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Sus scrofa)
        
        RPS6KA1 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287BHE2

Reference Genes

BioGPS Gene:100523972

ENSEMBL:ENSSSCG00000003558.5

Monarch:100523972

NCBI Gene:100523972

UCSC:A0A287BHE2

Reference Transcript

RefSeq:XM_021093347.1

Other Identifiers

100523972

GO:0000166

GO:0000287

GO:0003824

GO:0004672

GO:0004674

GO:0004711

GO:0004712

GO:0005524

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006468

GO:0016301

GO:0016740

GO:0032007

GO:0035556

GO:0038202

GO:0043066

GO:0045893

GO:0045944

GO:0106310

GO:0140096

GO:2000491

Ssc.2947.1.S1_at

Participates

as a member of

Ribosomal protein S6 kinase [nucleoplasm] (Sus scrofa)

Other forms of this molecule

phospho-p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol]

phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm]

Inferred From

RPS6KA1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_020949006.1

ENSEMBL

ENSSSCT00000044862, ENSSSCP00000055482, ENSSSCG00000003558

VGNC

92440

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