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SQSTM1 [cytosol]
Stable Identifier
R-SSC-193937
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
SQSTM1, A0A287BLE1
Locations in the PathwayBrowser
Expand all
Autophagy (Sus scrofa)
Macroautophagy (Sus scrofa)
Selective autophagy (Sus scrofa)
Mitophagy (Sus scrofa)
PINK1-PRKN Mediated Mitophagy (Sus scrofa)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Sus scrofa)
ATG5:ATG12:LC3:K48polyUB Mitophagy Substrates:SQSTM1 [phagocytic vesicle] (Sus scrofa)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Sus scrofa)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Sus scrofa)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
p62 binds ubiquitinated mitochondrial substrates (Sus scrofa)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
p62 links damaged mitochondria to LC3 (Sus scrofa)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Sus scrofa)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
Pexophagy (Sus scrofa)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Sus scrofa)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
ATM dimer:Ub-p-PEX5:SQSTM1:MAP1LC3B [peroxisomal membrane] (Sus scrofa)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Sus scrofa)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Sus scrofa)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1:MAP1LC3B [peroxisomal membrane] (Sus scrofa)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Sus scrofa)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Sus scrofa)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Sus scrofa)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Sus scrofa)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to chemical stress (Sus scrofa)
KEAP1-NFE2L2 pathway (Sus scrofa)
SQSTM1 oligomerizes (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
SQSTM1 oligomer [cytosol] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
TRIM21 ubiquitinates SQSTM1 (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
Immune System (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-1 family signaling (Sus scrofa)
Interleukin-1 signaling (Sus scrofa)
p62:MEKK3 binds to TRAF6 (Sus scrofa)
MAP3K3:SQSTM1 [cytosol] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Sus scrofa)
MAP3K3:SQSTM1 [cytosol] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Death Receptor Signaling (Sus scrofa)
p75 NTR receptor-mediated signalling (Sus scrofa)
p75NTR signals via NF-kB (Sus scrofa)
NF-kB is activated and signals survival (Sus scrofa)
IKKbeta is activated (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
p75NTR recruits signalling complexes (Sus scrofa)
IKK-beta is recruited (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
TRAF6 is auto-ubiquitinated (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
p62 is recruited and forms a complex with TRAF6 (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
p62 recruits an atypical PKC (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
SQSTM1 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A287BLE1
Gene Names
SQSTM1
Reference Genes
BioGPS Gene:100518718 SQSTM1
ENSEMBL:ENSSSCG00000014016.5
KEGG:ssc:100518718 SQSTM1
Monarch:100518718 SQSTM1
NCBI Gene:100518718 SQSTM1
UCSC:A0A287BLE1 SQSTM1
Reference Transcript
RefSeq:XM_003123639.3 SQSTM1
Other Identifiers
100518718
GO:0000122
GO:0000407
GO:0000423
GO:0000425
GO:0000932
GO:0001659
GO:0002376
GO:0005080
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005773
GO:0005776
GO:0005829
GO:0005929
GO:0006351
GO:0006355
GO:0006366
GO:0006606
GO:0006886
GO:0006913
GO:0006914
GO:0007005
GO:0007032
GO:0008270
GO:0010508
GO:0016234
GO:0016235
GO:0016236
GO:0016605
GO:0019899
GO:0019901
GO:0023052
GO:0030163
GO:0030674
GO:0031397
GO:0031625
GO:0034144
GO:0035255
GO:0035591
GO:0035973
GO:0036211
GO:0038023
GO:0042169
GO:0042802
GO:0043122
GO:0043130
GO:0043226
GO:0043231
GO:0043232
GO:0044753
GO:0044754
GO:0046872
GO:0060089
GO:0060090
GO:0061635
GO:0070342
GO:0070530
GO:0071211
GO:0072659
GO:0097009
GO:0097225
GO:0098542
GO:0098780
GO:0140036
GO:0140311
GO:0140313
GO:0140693
GO:0140694
GO:1900273
GO:1903078
GO:1905719
Ssc.3612.1.S1_at
Participates
as an input of
TRIM21 ubiquitinates SQSTM1 (Sus scrofa)
SQSTM1 oligomerizes (Sus scrofa)
p62 is recruited and forms a complex with TRAF6 (Sus scrofa)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Sus scrofa)
p62 binds ubiquitinated mitochondrial substrates (Sus scrofa)
as a component of
SQSTM1 oligomer [cytosol] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Sus scrofa)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
MAP3K3:SQSTM1 [cytosol] (Sus scrofa)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Sus scrofa)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Sus scrofa)
Other forms of this molecule
SQSTM1 [cytosol]
phospho-SQSTM1 [cytosol]
phospho-SQSTM1 [cytosol]
Inferred From
SQSTM1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_003123687.3
ENSEMBL
ENSSSCG00000014016
,
ENSSSCP00000056985
,
ENSSSCT00000036969
VGNC
93445
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