Reactome | Klotho bound to FGF23 [plasma membrane]

Klotho bound to FGF23 [plasma membrane]

Stable Identifier

R-SSC-190208

Type

Complex

Species

Sus scrofa

Compartment

plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - PIP3 activates AKT signaling (Sus scrofa)
    - Negative regulation of the PI3K/AKT network (Sus scrofa)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
        
        PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        Activator:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
    - PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
      - Activator:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
- MAPK family signaling cascades (Sus scrofa)
  - MAPK1/MAPK3 signaling (Sus scrofa)
    - RAF/MAP kinase cascade (Sus scrofa)
      - RAS GEFs promote RAS nucleotide exchange (Sus scrofa)
        
        RAS GEFs [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-SHC1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by FGFR (Sus scrofa)
    - Signaling by FGFR1 (Sus scrofa)
      - Downstream signaling of activated FGFR1 (Sus scrofa)
        
        Activated FGFR1 binds FLRT1,2,3 (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:FLRT [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        FRS-mediated FGFR1 signaling (Sus scrofa)
        
        Activated FGFR1 binds FRS2 (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 binds FRS3 (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 phosphorylates FRS2 (Sus scrofa)
        
        Activated FGFR1:FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 phosphorylates FRS3 (Sus scrofa)
        
        Activated FGFR1:FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS bind to PPTN11 (Sus scrofa)
        
        Activated FGFR1:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS binds GRB2:SOS1 (Sus scrofa)
        
        Activated FGFR1:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS phosphorylates PPTN11 (Sus scrofa)
        
        Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)
        
        Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)
        
        Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS3 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        PI-3K cascade:FGFR1 (Sus scrofa)
        
        Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)
        
        Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Phospholipase C-mediated cascade: FGFR1 (Sus scrofa)
        
        Activated FGFR1 binds PLCG1 (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        activated FGFR1:PLCG1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 phosphorylates PLCG1 (Sus scrofa)
        
        activated FGFR1:PLCG1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        p-4Y-PLCG1 dissociates from activated FGFR1 (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        SHC-mediated cascade:FGFR1 (Sus scrofa)
        
        Activated FGFR1 binds SHC1 (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:SHC1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 phosphorylates SHC1 (Sus scrofa)
        
        Activated FGFR1:SHC1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-SHC1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Sus scrofa)
        
        Activated FGFR1:p-SHC1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-SHC1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)
        
        Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-SHC1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
      - FGFR1 ligand binding and activation (Sus scrofa)
        
        FGFR1c and Klotho ligand binding and activation (Sus scrofa)
        
        Autocatalytic phosphorylation of Klotho-bound FGFR1c (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        FGF23 bound to Klotho and FGFR1c [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        FGFR1c binds to Klotho-bound FGF23 (Sus scrofa)
        
        FGF23 bound to Klotho and FGFR1c [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
      - Negative regulation of FGFR1 signaling (Sus scrofa)
        
        Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Sus scrofa)
        
        Activated FGFR1:FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-8T-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        CBL ubiquitinates FRS2 and FGFR1 (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1 [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
  - Signaling by Insulin receptor (Sus scrofa)
    - Insulin receptor signalling cascade (Sus scrofa)
      - IRS-mediated signalling (Sus scrofa)
        
        PI3K Cascade (Sus scrofa)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
        
        PI3K-containing complexes [cytosol] (Sus scrofa)
        
        Activated FGFR bound to PI3K [cytosol] (Sus scrofa)
        
        GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Sus scrofa)
        
        Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Sus scrofa)
    - IGF1R signaling cascade (Sus scrofa)
      - IRS-related events triggered by IGF1R (Sus scrofa)
        
        IRS-mediated signalling (Sus scrofa)
        
        PI3K Cascade (Sus scrofa)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
        
        PI3K-containing complexes [cytosol] (Sus scrofa)
        
        Activated FGFR bound to PI3K [cytosol] (Sus scrofa)
        
        GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Sus scrofa)
        
        Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Sus scrofa)
        
        Activated FGFR:p-FRS2 [plasma membrane] (Sus scrofa)
        
        Activated FGFR [plasma membrane] (Sus scrofa)
        
        Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Sus scrofa)
        
        Klotho bound to FGF23 [plasma membrane] (Sus scrofa)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as an input of

FGFR1c binds to Klotho-bound FGF23 (Sus scrofa)

as a component of

Inferred From

Klotho bound to FGF23 [plasma membrane] (Homo sapiens)

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