Reactome | SH3KBP1 [cytosol]

SH3KBP1 [cytosol]

Stable Identifier

R-SSC-182957

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

SH3KBP1, A0A481CIL9

Locations in the PathwayBrowser

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Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Signaling by the B Cell Receptor (BCR) (Sus scrofa)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Sus scrofa)
      - p-6Y-SYK phosphorylates BLNK (SLP65) (Sus scrofa)
        
        BLNK:GRB2:SOS1:CIN85 [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by EGFR (Sus scrofa)
    - EGFR downregulation (Sus scrofa)
      - Assembly of EGFR complex in clathrin-coated vesicles (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - CBL-mediated ubiquitination of CIN85 (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - EGFR binds EPS15, EPN1, EPS15L1 (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - EGFR non-clathrin mediated endocytosis (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - EGFR phosphorylates EPS15 (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - PTPN3 dephosphorylates EPS15 (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - Sprouty sequesters CBL away from active EGFR (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
  - Signaling by MET (Sus scrofa)
    - Negative regulation of MET activity (Sus scrofa)
      - CBL recruits CIN85:endophilin to ubiquitinated MET (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - EPS15 and HGS bind ubiquitinated MET (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Sus scrofa)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - Clathrin-mediated endocytosis (Sus scrofa)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
    - BAR domain proteins recruit dynamin (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Sus scrofa)
      - CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
    - Cargo recognition for clathrin-mediated endocytosis (Sus scrofa)
      - Epsin family proteins bind ubiquitinated cargo (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
    - Clathrin recruits PIK3C2A (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Sus scrofa)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
    - RAB5 and GAPVD1 bind AP-2 (Sus scrofa)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
    - SNX9 recruits components of the actin polymerizing machinery (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        ubiquitinated cargo [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Sus scrofa)
        
        CIN85:endophilin [cytosol] (Sus scrofa)
        
        SH3KBP1 tetramer [cytosol] (Sus scrofa)
        
        SH3KBP1 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A481CIL9

Gene Names

SH3KBP1

Reference Genes

BioGPS Gene:100522530 SH3KBP1

ENSEMBL:ENSSSCG00000012160.6

Monarch:100522530 SH3KBP1

NCBI Gene:100522530 SH3KBP1

UCSC:A0A481CIL9 SH3KBP1

Reference Transcript

RefSeq:XM_021080257.1 SH3KBP1

Other Identifiers

GO:0005515

GO:0005737

GO:0005856

GO:0005911

GO:0005925

GO:0006897

GO:0006915

GO:0007010

GO:0007015

GO:0008360

GO:0016020

GO:0016192

GO:0016301

GO:0016477

GO:0017124

GO:0030139

GO:0030659

GO:0031410

GO:0043005

GO:0045202

GO:0048870

GO:0050871

GO:0070161

Ssc.11185.1.A1_at

Ssc.11185.2.S1_at

Participates

as an input of

RELN:VLDLR:DAB1 binds SH3KBP1 (Sus scrofa)

as a component of

Other forms of this molecule

SH3KBP1 [cytosol]

SH3KBP1 [plasma membrane]

Inferred From

SH3KBP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_020935916.1

ENSEMBL

ENSSSCG00000012160, ENSSSCT00000078861, ENSSSCP00000062992

VGNC

92828

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