Reactome | PSMD3 [nucleoplasm]

PSMD3 [nucleoplasm]

Stable Identifier

R-SSC-174328

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

PSMD3, F1RXA7

Locations in the PathwayBrowser

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Cell Cycle (Sus scrofa)

- Cell Cycle Checkpoints (Sus scrofa)
  - G1/S DNA Damage Checkpoints (Sus scrofa)
    - p53-Independent G1/S DNA Damage Checkpoint (Sus scrofa)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Sus scrofa)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Sus scrofa)
        
        26S proteasome [nucleoplasm] (Sus scrofa)
        
        19S regulatory particle [nucleoplasm] (Sus scrofa)
        
        19S RP lid [nucleoplasm] (Sus scrofa)
        
        19S RP lid particle 2 [nucleoplasm] (Sus scrofa)
        
        19S RP lid particle 3 [nucleoplasm] (Sus scrofa)
        
        PSMD3 [nucleoplasm] (Sus scrofa)
- Cell Cycle, Mitotic (Sus scrofa)
  - Mitotic G1 phase and G1/S transition (Sus scrofa)
    - G1/S Transition (Sus scrofa)
      - Cyclin E associated events during G1/S transition (Sus scrofa)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Sus scrofa)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Sus scrofa)
        
        26S proteasome [nucleoplasm] (Sus scrofa)
        
        19S regulatory particle [nucleoplasm] (Sus scrofa)
        
        19S RP lid [nucleoplasm] (Sus scrofa)
        
        19S RP lid particle 2 [nucleoplasm] (Sus scrofa)
        
        19S RP lid particle 3 [nucleoplasm] (Sus scrofa)
        
        PSMD3 [nucleoplasm] (Sus scrofa)
  - Regulation of mitotic cell cycle (Sus scrofa)
    - APC/C-mediated degradation of cell cycle proteins (Sus scrofa)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Sus scrofa)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Sus scrofa)
        
        26S proteasome [nucleoplasm] (Sus scrofa)
        
        19S regulatory particle [nucleoplasm] (Sus scrofa)
        
        19S RP lid [nucleoplasm] (Sus scrofa)
        
        19S RP lid particle 2 [nucleoplasm] (Sus scrofa)
        
        19S RP lid particle 3 [nucleoplasm] (Sus scrofa)
        
        PSMD3 [nucleoplasm] (Sus scrofa)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Sus scrofa)
        
        Degradation of multiubiquitinated Cdh1 (Sus scrofa)
        
        26S proteasome [nucleoplasm] (Sus scrofa)
        
        19S regulatory particle [nucleoplasm] (Sus scrofa)
        
        19S RP lid [nucleoplasm] (Sus scrofa)
        
        19S RP lid particle 2 [nucleoplasm] (Sus scrofa)
        
        19S RP lid particle 3 [nucleoplasm] (Sus scrofa)
        
        PSMD3 [nucleoplasm] (Sus scrofa)
  - S Phase (Sus scrofa)
    - Cyclin A:Cdk2-associated events at S phase entry (Sus scrofa)
      - SCF(Skp2)-mediated degradation of p27/p21 (Sus scrofa)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Sus scrofa)
        
        26S proteasome [nucleoplasm] (Sus scrofa)
        
        19S regulatory particle [nucleoplasm] (Sus scrofa)
        
        19S RP lid [nucleoplasm] (Sus scrofa)
        
        19S RP lid particle 2 [nucleoplasm] (Sus scrofa)
        
        19S RP lid particle 3 [nucleoplasm] (Sus scrofa)
        
        PSMD3 [nucleoplasm] (Sus scrofa)

DNA Replication (Sus scrofa)

- DNA Replication Pre-Initiation (Sus scrofa)
  - Assembly of the pre-replicative complex (Sus scrofa)
    - Ubiquitinated geminin is degraded by the proteasome (Sus scrofa)
      - 26S proteasome [nucleoplasm] (Sus scrofa)
        
        19S regulatory particle [nucleoplasm] (Sus scrofa)
        
        19S RP lid [nucleoplasm] (Sus scrofa)
        
        19S RP lid particle 2 [nucleoplasm] (Sus scrofa)
        
        19S RP lid particle 3 [nucleoplasm] (Sus scrofa)
        
        PSMD3 [nucleoplasm] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional regulation by RUNX2 (Sus scrofa)
      - Regulation of RUNX2 expression and activity (Sus scrofa)
        
        26S proteasome degrades PolyUb-RUNX2 (Sus scrofa)
        
        26S proteasome [nucleoplasm] (Sus scrofa)
        
        19S regulatory particle [nucleoplasm] (Sus scrofa)
        
        19S RP lid [nucleoplasm] (Sus scrofa)
        
        19S RP lid particle 2 [nucleoplasm] (Sus scrofa)
        
        19S RP lid particle 3 [nucleoplasm] (Sus scrofa)
        
        PSMD3 [nucleoplasm] (Sus scrofa)
    - Transcriptional regulation by RUNX3 (Sus scrofa)
      - Regulation of RUNX3 expression and activity (Sus scrofa)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Sus scrofa)
        
        26S proteasome [nucleoplasm] (Sus scrofa)
        
        19S regulatory particle [nucleoplasm] (Sus scrofa)
        
        19S RP lid [nucleoplasm] (Sus scrofa)
        
        19S RP lid particle 2 [nucleoplasm] (Sus scrofa)
        
        19S RP lid particle 3 [nucleoplasm] (Sus scrofa)
        
        PSMD3 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1RXA7

Gene Names

PSMD3

Reference Genes

BioGPS Gene:100512253 PSMD3

ENSEMBL:ENSSSCG00000017489.5

KEGG:ssc:100512253 PSMD3

Monarch:100512253 PSMD3

NCBI Gene:100512253 PSMD3

UCSC:F1RXA7 PSMD3

Reference Transcript

RefSeq:XM_003131496.5 PSMD3

Other Identifiers

100512253

GO:0000502

GO:0005654

GO:0005829

GO:0005838

GO:0006511

GO:0008541

GO:0022624

GO:0030234

GO:0042176

Ssc.16843.1.S1_at

Ssc.16843.2.S1_at

Participates

as a component of

19S RP lid particle 3 [nucleoplasm] (Sus scrofa)

Other forms of this molecule

PSMD3 [secretory granule lumen]

PSMD3 [extracellular region]

PSMD3 [ficolin-1-rich granule lumen]

PSMD3 [cytosol]

Inferred From

PSMD3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_003131544.1

ENSEMBL

ENSSSCT00000019042, ENSSSCG00000017489, ENSSSCP00000018537

VGNC

91922

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