Reactome | UBE2C [nucleoplasm]

UBE2C [nucleoplasm]

Stable Identifier

R-SSC-174188

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

UBE2C, A0A4X1U068

Locations in the PathwayBrowser

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Cell Cycle (Sus scrofa)

- Cell Cycle, Mitotic (Sus scrofa)
  - Regulation of mitotic cell cycle (Sus scrofa)
    - APC/C-mediated degradation of cell cycle proteins (Sus scrofa)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Sus scrofa)
        
        APC/C:Cdh1 polyubiquitinates SKP2 (Sus scrofa)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Sus scrofa)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Sus scrofa)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Sus scrofa)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Sus scrofa)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        RB1 recruits APC/C:Cdh1 complex to SKP2 (Sus scrofa)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Sus scrofa)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Sus scrofa)
        
        Phosphorylation of the APC/C (Sus scrofa)
        
        Free APC/C phosphorylated by Cyclin B:Cdc2 (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        Free APC/C phosphorylated by Plk1 (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Sus scrofa)
        
        Degradation of multiubiquitinated Cdh1 (Sus scrofa)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Sus scrofa)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        Multiubiquitination of APC/C-associated Cdh1 (Sus scrofa)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Sus scrofa)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
      - Regulation of APC/C activators between G1/S and early anaphase (Sus scrofa)
        
        Association of Cyclin A:Cdk2 with Cdh1 (Sus scrofa)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        Dissociation of phospho-Cdh1 from the APC/C complex (Sus scrofa)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Sus scrofa)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)

Cellular responses to stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Cellular Senescence (Sus scrofa)
    - Senescence-Associated Secretory Phenotype (SASP) (Sus scrofa)
      - CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Sus scrofa)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
      - CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Sus scrofa)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
      - Cdh1:APC/C complex binds EHMT1:EHMT2 (Sus scrofa)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Sus scrofa)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
      - Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Sus scrofa)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Sus scrofa)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)
        
        Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Sus scrofa)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Protein ubiquitination (Sus scrofa)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Sus scrofa)
      - UBA1 conjugates ubiquitin to nuclear E2 enzymes (Sus scrofa)
        
        E2 ubiquitin conjugating enzyme (UBA1 substrate) [nucleoplasm] (Sus scrofa)
        
        UBE2C [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A4X1U068

Gene Names

UBE2C

Reference Genes

BioGPS Gene:100153133 UBE2C

ENSEMBL:ENSSSCG00000007423.5

KEGG:ssc:100153133 UBE2C

Monarch:100153133 UBE2C

NCBI Gene:100153133 UBE2C

UCSC:A0A4X1U068 UBE2C

Reference Transcript

RefSeq:XM_013985422.2 UBE2C

Other Identifiers

100153133

GO:0000151

GO:0000166

GO:0000209

GO:0003824

GO:0004842

GO:0005524

GO:0005634

GO:0005680

GO:0005829

GO:0005886

GO:0006511

GO:0010458

GO:0010994

GO:0016567

GO:0016740

GO:0030071

GO:0030163

GO:0031145

GO:0031146

GO:0031536

GO:0043161

GO:0044389

GO:0045842

GO:0051301

GO:0061631

GO:0070936

GO:0070979

GO:0140096

Ssc.27540.2.S1_at

Participates

as a member of

E2 ubiquitin conjugating enzyme (UBA1 substrate) [nucleoplasm] (Sus scrofa)

as a component of

phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Sus scrofa)

Other forms of this molecule

UBE2C [cytosol]

UBE2C [nucleoplasm]

UBE2C [cytosol]

Inferred From

UBE2C [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_013840876.1

ENSEMBL

ENSSSCG00000007423, ENSSSCP00000007910, ENSSSCT00000008126

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