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MAP3K14 [cytosol]
Stable Identifier
R-SSC-168189
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
F1RR25
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Regulation of T cell activation by CD28 family (Sus scrofa)
Co-stimulation by CD28 (Sus scrofa)
CD28 dependent PI3K/Akt signaling (Sus scrofa)
p-S400-Cot phosphorylates NIK (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
TNFR2 non-canonical NF-kB pathway (Sus scrofa)
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Sus scrofa)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Sus scrofa)
K48polyUb-TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
NIK-->noncanonical NF-kB signaling (Sus scrofa)
Activation of NIK (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
Active NIK phosphorylates IKKA dimer (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
NIK autophosphorylates on T559 (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
p100:RELB binds active NIK:p-IKKA dimer (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
Protesomal degradation of K48polyUb-TRAF3 (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Sus scrofa)
K48polyUb-TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Sus scrofa)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Sus scrofa)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Sus scrofa)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
TRAF2:cIAP1/2 complex binds FN14:TWEAK (Sus scrofa)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
TRAF3 binds BAFFR:BAFF (Sus scrofa)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
TRAFs bind RANK:RANKL (Sus scrofa)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Sus scrofa)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Sus scrofa)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
TRAF3:NIK binds TRAF2:cIAP1/2 (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Sus scrofa)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Sus scrofa)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Sus scrofa)
TRAF3:NIK [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
Innate Immune System (Sus scrofa)
C-type lectin receptors (CLRs) (Sus scrofa)
CLEC7A (Dectin-1) signaling (Sus scrofa)
Dectin-1 mediated noncanonical NF-kB signaling (Sus scrofa)
Activation of NIK (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
Active NIK phosphorylates IKKA dimer (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
p100:RELB binds active NIK:p-IKKA dimer (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Sus scrofa)
MAP3K14 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:F1RR25
Reference Genes
ENSEMBL:ENSSSCG00000017330.6
UCSC:F1RR25
Other Identifiers
100520402
GO:0000165
GO:0000166
GO:0001650
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004709
GO:0005524
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006955
GO:0007249
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0038061
GO:0043226
GO:0043231
GO:0051607
GO:0071260
GO:0098542
GO:0140096
Ssc.8628.1.A1_at
Participates
as an input of
NIK autophosphorylates on T559 (Sus scrofa)
Active NIK phosphorylates IKKA dimer (Sus scrofa)
Activation of NIK (Sus scrofa)
p-S400-Cot phosphorylates NIK (Sus scrofa)
as an output of
Activation of NIK (Sus scrofa)
Protesomal degradation of K48polyUb-TRAF3 (Sus scrofa)
as a component of
TRAF3:NIK [cytosol] (Sus scrofa)
K48polyUb-TRAF3:NIK [cytosol] (Sus scrofa)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Sus scrofa)
Other forms of this molecule
phospho-p-T559-MAP3K14 [cytosol]
K48polyUb-NIK [cytosol]
phospho-p-MAP3K14 [cytosol]
Inferred From
MAP3K14 [cytosol]
(Homo sapiens)
Active NIK [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSSSCG00000017330
,
ENSSSCT00000018866
,
ENSSSCP00000018362
VGNC
98105
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