Reactome | NGF [extracellular region]

NGF [extracellular region]

Stable Identifier

R-SSC-167034

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

extracellular region

Synonyms

NGF, A0A287BL61

Locations in the PathwayBrowser

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Signal Transduction (Sus scrofa)

- Death Receptor Signaling (Sus scrofa)
  - p75 NTR receptor-mediated signalling (Sus scrofa)
    - Cell death signalling via NRAGE, NRIF and NADE (Sus scrofa)
      - NADE modulates death signalling (Sus scrofa)
        
        14-3-3epsilon attentuates NADE-related apoptosis (Sus scrofa)
        
        NGF ligand:p75NTR:NADE:14-3-3epsilon [plasma membrane] (Sus scrofa)
        
        NGF:p75NTR:NADE [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        NGF:p75NTR:NADE [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        p75NTR binds to NADE (Sus scrofa)
        
        NGF:p75NTR:NADE [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        p75NTR:NADE promotes caspase2/3 activation (Sus scrofa)
        
        NGF:p75NTR:NADE [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
    - NFG and proNGF binds to p75NTR (Sus scrofa)
      - NGF homodimer binds to p75NTR (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
    - p75NTR regulates axonogenesis (Sus scrofa)
      - Axonal growth stimulation (Sus scrofa)
        
        NGF binding to p75NTR inactivates RHOA (Sus scrofa)
        
        RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
    - p75NTR signals via NF-kB (Sus scrofa)
      - NF-kB is activated and signals survival (Sus scrofa)
        
        IKKbeta is activated (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        IKKbeta phosphorylates IkB causing NF-kB to dissociate (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
      - p75NTR recruits signalling complexes (Sus scrofa)
        
        IKK-beta is recruited (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        IRAK interacts with TRAF6 (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Sus scrofa)
        
        NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        MYD88 dissociates (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Sus scrofa)
        
        NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        TRAF6 is auto-ubiquitinated (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        p62 is recruited and forms a complex with TRAF6 (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        p62 recruits an atypical PKC (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Sus scrofa)
        
        NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        p75NTR interacts with RIP2 (Sus scrofa)
        
        NGF:p75NTR:RIP2 [plasma membrane] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        mature NGF homodimer:p75NTR [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by NTRKs (Sus scrofa)
    - Expression and Processing of Neurotrophins (Sus scrofa)
      - NGF processing (Sus scrofa)
        
        Pro-beta-NGF and mature beta-NGF are secreted (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
    - Signaling by NTRK1 (TRKA) (Sus scrofa)
      - Activation of TRKA receptors (Sus scrofa)
        
        TRKA activation by NGF (Sus scrofa)
        
        Activated TrkA receptor internalizes to endosomes (Sus scrofa)
        
        Activated TrkA receptor complex [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        The bound receptor dimerizes (Sus scrofa)
        
        beta-NGF dimer:TrkA receptor [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        beta-NGF dimer:TrkA receptor dimer [plasma membrane] (Sus scrofa)
        
        beta-NGF dimer:TrkA receptor [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        beta-NGF dimer binds to TrkA receptor (Sus scrofa)
        
        beta-NGF dimer:TrkA receptor [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
      - PI3K/AKT activation (Sus scrofa)
        
        Active IRS recruits PI3K to the plasma membrane and activates it (Sus scrofa)
        
        Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Sus scrofa)
        
        Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        PI3K produces PIP3 and other phosphatidyl inositides (Sus scrofa)
        
        Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Sus scrofa)
        
        Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
      - Signalling to ERKs (Sus scrofa)
        
        Prolonged ERK activation events (Sus scrofa)
        
        ARMS-mediated activation (Sus scrofa)
        
        ARMS is phosphorylated by active TrkA receptor (Sus scrofa)
        
        Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Sus scrofa)
        
        Activated TrkA receptor complex [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Sus scrofa)
        
        Activated TrkA receptor complex [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        C3G stimulates nucleotide exchange on Rap1 (Sus scrofa)
        
        Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Sus scrofa)
        
        Activated TrkA receptor complex [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)
        
        Crk's SH3 domain engages C3G (Sus scrofa)
        
        Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Sus scrofa)
        
        Activated TrkA receptor complex [plasma membrane] (Sus scrofa)
        
        mature beta-NGF homodimer [extracellular region] (Sus scrofa)
        
        NGF [extracellular region] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287BL61

Gene Names

NGF

Reference Genes

BioGPS Gene:100738968 NGF

ENSEMBL:ENSSSCG00000032417.3

KEGG:ssc:100738968 NGF

Monarch:100738968 NGF

NCBI Gene:100738968 NGF

UCSC:A0A287BL61 NGF

Reference Transcript

Other Identifiers

100738968

GO:0004857

GO:0005102

GO:0005163

GO:0005576

GO:0005615

GO:0007169

GO:0007422

GO:0007623

GO:0008021

GO:0008083

GO:0008191

GO:0008625

GO:0010628

GO:0010976

GO:0014042

GO:0019233

GO:0021675

GO:0030297

GO:0030414

GO:0030424

GO:0030425

GO:0031175

GO:0031398

GO:0031410

GO:0038180

GO:0043524

GO:0045664

GO:0045773

GO:0046579

GO:0046928

GO:0048011

GO:0048018

GO:0048672

GO:0048675

GO:0048812

GO:0048856

GO:0050804

GO:0050877

GO:0051279

GO:0051402

GO:0051897

GO:0070374

GO:0097192

GO:0098772

Ssc.19976.1.S1_at

Participates

as a component of

mature beta-NGF homodimer [extracellular region] (Sus scrofa)

Other forms of this molecule

NGF [extracellular region]

NGF [Golgi lumen]

NGF [cytosol]

NGF [Golgi lumen]

Inferred From

NGF [extracellular region] (Homo sapiens)

Cross References

RefSeq

XP_020945656.1, XP_020945655.1

ENSEMBL

ENSSSCT00000058911, ENSSSCP00000056905, ENSSSCG00000032417

VGNC

98826

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