Reactome | SP1 [nucleoplasm]

SP1 [nucleoplasm]

Stable Identifier

R-SSC-1592223

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

SP1, A0A286ZZJ6

Locations in the PathwayBrowser

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Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Sus scrofa)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Sus scrofa)
        
        SMAD2/3:SMAD4 heterotrimer binds SP1 (Sus scrofa)
        
        SP1 [nucleoplasm] (Sus scrofa)
        
        p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Sus scrofa)
        
        SP1 [nucleoplasm] (Sus scrofa)
  - RNA polymerase II transcribes snRNA genes (Sus scrofa)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SP1 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SP1 [nucleoplasm] (Sus scrofa)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Sus scrofa)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Sus scrofa)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SP1 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Sus scrofa)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SP1 [nucleoplasm] (Sus scrofa)
    - Integrator complex processes the 3' end of snRNA (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SP1 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SP1 [nucleoplasm] (Sus scrofa)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SP1 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SP1 [nucleoplasm] (Sus scrofa)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Sus scrofa)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SP1 [nucleoplasm] (Sus scrofa)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SP1 [nucleoplasm] (Sus scrofa)
    - RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Sus scrofa)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SP1 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Sus scrofa)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SP1 [nucleoplasm] (Sus scrofa)
    - RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Sus scrofa)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Sus scrofa)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SP1 [nucleoplasm] (Sus scrofa)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Sus scrofa)
        
        SP1 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A286ZZJ6

Gene Names

SP1

Reference Genes

BioGPS Gene:396575 SP1

ENSEMBL:ENSSSCG00000000272.4

KEGG:ssc:396575 SP1

Monarch:396575 SP1

NCBI Gene:396575 SP1

UCSC:A0A286ZZJ6 SP1

Reference Transcript

RefSeq:XM_005652567.3 SP1

Other Identifiers

396575

GO:0000785

GO:0000791

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0001221

GO:0001228

GO:0003677

GO:0003690

GO:0003700

GO:0005634

GO:0005654

GO:0006355

GO:0006357

GO:0008270

GO:0010628

GO:0017053

GO:0042802

GO:0042803

GO:0042826

GO:0043536

GO:0043565

GO:0043923

GO:0045766

GO:0045893

GO:0045944

GO:0046872

GO:1902004

GO:1904828

GO:1905564

GO:1990837

GO:2001235

Ssc.18559.1.S1_at

Participates

as an input of

as a component of

Inferred From

SP1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_005652624.1

ENSEMBL

ENSSSCG00000000272, ENSSSCT00000065738, ENSSSCP00000037064

VGNC

93360

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