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TIMP2 [extracellular region]
Stable Identifier
R-SSC-1454879
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
extracellular region
Synonyms
C0JPM4
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Sus scrofa)
Degradation of the extracellular matrix (Sus scrofa)
Activation of Matrix Metalloproteinases (Sus scrofa)
Autocatalytic activation of bound proMMP2 (Sus scrofa)
MMP14:TIMP2:MMP2 intermediate form [plasma membrane] (Sus scrofa)
MMP14:TIMP2 [plasma membrane] (Sus scrofa)
TIMP2 [extracellular region] (Sus scrofa)
MMP14:TIMP:MMP2 [plasma membrane] (Sus scrofa)
MMP14:TIMP2 [plasma membrane] (Sus scrofa)
TIMP2 [extracellular region] (Sus scrofa)
Initial activation of proMMP2 by MMP14 (Sus scrofa)
MMP14:TIMP2:MMP2 intermediate form [plasma membrane] (Sus scrofa)
MMP14:TIMP2 [plasma membrane] (Sus scrofa)
TIMP2 [extracellular region] (Sus scrofa)
MMP14:TIMP2:proMMP2 [plasma membrane] (Sus scrofa)
MMP14:TIMP2 [plasma membrane] (Sus scrofa)
TIMP2 [extracellular region] (Sus scrofa)
MMP14 (MT1-MMP) binds TIMP2 (Sus scrofa)
MMP14:TIMP2 [plasma membrane] (Sus scrofa)
TIMP2 [extracellular region] (Sus scrofa)
TIMP2 [extracellular region] (Sus scrofa)
MMP14:TIMP2 binds proMMP2 (Sus scrofa)
MMP14:TIMP2 [plasma membrane] (Sus scrofa)
TIMP2 [extracellular region] (Sus scrofa)
MMP14:TIMP2:proMMP2 [plasma membrane] (Sus scrofa)
MMP14:TIMP2 [plasma membrane] (Sus scrofa)
TIMP2 [extracellular region] (Sus scrofa)
Immune System (Sus scrofa)
Innate Immune System (Sus scrofa)
Neutrophil degranulation (Sus scrofa)
Exocytosis of ficolin-rich granule lumen proteins (Sus scrofa)
Ficolin-rich granule lumen proteins [extracellular region] (Sus scrofa)
TIMP2 [extracellular region] (Sus scrofa)
Exocytosis of specific granule lumen proteins (Sus scrofa)
Specific granule lumen proteins [extracellular region] (Sus scrofa)
TIMP2 [extracellular region] (Sus scrofa)
Exocytosis of tertiary granule lumen proteins (Sus scrofa)
Tertiary granule lumen proteins [extracellular region] (Sus scrofa)
TIMP2 [extracellular region] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by TGFB family members (Sus scrofa)
Signaling by TGFBR3 (Sus scrofa)
TGFBR3 PTM regulation (Sus scrofa)
TGFBR3_mem cleavage by MMPs (Sus scrofa)
TIMP2 [extracellular region] (Sus scrofa)
External Reference Information
External Reference
UniProt:C0JPM4
Reference Genes
BioGPS Gene:396988
ENSEMBL:ENSSSCG00000017164.5
KEGG:ssc:396988
Monarch:396988
NCBI Gene:396988
UCSC:C0JPM4
Reference Transcript
RefSeq:NM_001145985.1
Other Identifiers
396988
GO:0004857
GO:0005515
GO:0005576
GO:0005615
GO:0006508
GO:0008191
GO:0008233
GO:0008237
GO:0009725
GO:0030312
GO:0030414
GO:0031012
GO:0034097
GO:0046872
GO:0051045
GO:0098772
Ssc.1082.1.S1_at
Ssc.11257.1.S1_at
Participates
as an input of
MMP14 (MT1-MMP) binds TIMP2 (Sus scrofa)
as a component of
MMP14:TIMP2 [plasma membrane] (Sus scrofa)
as a member of
Specific granule lumen proteins [extracellular region] (Sus scrofa)
Ficolin-rich granule lumen proteins [extracellular region] (Sus scrofa)
Tertiary granule lumen proteins [extracellular region] (Sus scrofa)
This entity regulates
Negatively
TGFBR3_mem cleavage by MMPs
(Sus scrofa)
Other forms of this molecule
TIMP2 [specific granule lumen]
TIMP2 [ficolin-1-rich granule lumen]
TIMP2 [tertiary granule lumen]
Inferred From
TIMP2 [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_001139457.1
ENSEMBL
ENSSSCG00000017164
,
ENSSSCT00000018688
,
ENSSSCP00000018187
VGNC
93995
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