Reactome | CYBA [phagocytic vesicle membrane]

CYBA [phagocytic vesicle membrane]

Stable Identifier

R-SSC-1222756

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

phagocytic vesicle membrane

Synonyms

CYBA, A0A287BG06

Locations in the PathwayBrowser

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Cellular responses to stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Cellular response to chemical stress (Sus scrofa)
    - Detoxification of Reactive Oxygen Species (Sus scrofa)
      - NOX2 generates superoxide from oxygen (Sus scrofa)
        
        NOX2 complex [phagocytic vesicle membrane] (Sus scrofa)
        
        Cytochrome b-245 [phagocytic vesicle membrane] (Sus scrofa)
        
        CYBA [phagocytic vesicle membrane] (Sus scrofa)

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Class I MHC mediated antigen processing & presentation (Sus scrofa)
    - Antigen processing-Cross presentation (Sus scrofa)
      - Cross-presentation of particulate exogenous antigens (phagosomes) (Sus scrofa)
        
        Alkalization of the phagosomal lumen by NOX2 (Sus scrofa)
        
        NOX2 complex [phagocytic vesicle membrane] (Sus scrofa)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Sus scrofa)
        
        CYBA [phagocytic vesicle membrane] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - ROS and RNS production in phagocytes (Sus scrofa)
    - NOX2 generates superoxide anion from oxygen (Sus scrofa)
      - NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Sus scrofa)
        
        NOX2 complex [phagocytic vesicle membrane] (Sus scrofa)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Sus scrofa)
        
        CYBA [phagocytic vesicle membrane] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
  - Signaling by Rho GTPases (Sus scrofa)
    - RHO GTPase Effectors (Sus scrofa)
      - RHO GTPases Activate NADPH Oxidases (Sus scrofa)
        
        Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Sus scrofa)
        
        NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Sus scrofa)
        
        NOX2 complex [phagocytic vesicle membrane] (Sus scrofa)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Sus scrofa)
        
        CYBA [phagocytic vesicle membrane] (Sus scrofa)
        
        NOX2 complex:S100A8:S100A9:Ca2+ [phagocytic vesicle membrane] (Sus scrofa)
        
        NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Sus scrofa)
        
        NOX2 complex [phagocytic vesicle membrane] (Sus scrofa)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Sus scrofa)
        
        CYBA [phagocytic vesicle membrane] (Sus scrofa)
        
        RAC2:GTP binds NOX2 complex (Sus scrofa)
        
        NOX2 complex [phagocytic vesicle membrane] (Sus scrofa)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Sus scrofa)
        
        CYBA [phagocytic vesicle membrane] (Sus scrofa)
        
        NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Sus scrofa)
        
        NOX2 complex [phagocytic vesicle membrane] (Sus scrofa)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Sus scrofa)
        
        CYBA [phagocytic vesicle membrane] (Sus scrofa)
        
        S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Sus scrofa)
        
        NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Sus scrofa)
        
        NOX2 complex [phagocytic vesicle membrane] (Sus scrofa)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Sus scrofa)
        
        CYBA [phagocytic vesicle membrane] (Sus scrofa)
        
        NOX2 complex:S100A8:S100A9:Ca2+ [phagocytic vesicle membrane] (Sus scrofa)
        
        NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Sus scrofa)
        
        NOX2 complex [phagocytic vesicle membrane] (Sus scrofa)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Sus scrofa)
        
        CYBA [phagocytic vesicle membrane] (Sus scrofa)
    - RHO GTPase cycle (Sus scrofa)
      - RAC2 GTPase cycle (Sus scrofa)
        
        RAC2 binds effectors at the phagocytic vesicle membrane (Sus scrofa)
        
        NOX2 complex [phagocytic vesicle membrane] (Sus scrofa)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Sus scrofa)
        
        CYBA [phagocytic vesicle membrane] (Sus scrofa)
        
        NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Sus scrofa)
        
        NOX2 complex [phagocytic vesicle membrane] (Sus scrofa)
        
        flavocytochrome b558 catalytic core [phagocytic vesicle membrane] (Sus scrofa)
        
        CYBA [phagocytic vesicle membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287BG06

Gene Names

CYBA

Reference Genes

ENSEMBL:ENSSSCG00000031493.3

Other Identifiers

397507

GO:0002376

GO:0003824

GO:0005737

GO:0005768

GO:0005886

GO:0006091

GO:0006801

GO:0006954

GO:0009055

GO:0016020

GO:0016175

GO:0016192

GO:0016491

GO:0017004

GO:0017124

GO:0020037

GO:0022900

GO:0023052

GO:0031410

GO:0032755

GO:0032760

GO:0034137

GO:0042554

GO:0043020

GO:0043226

GO:0045087

GO:0045730

GO:0046982

GO:0050766

GO:0051279

GO:0051649

GO:0055065

GO:0055085

GO:0065003

GO:0070254

GO:0070257

GO:0072593

GO:0098542

GO:1900426

GO:1903428

Ssc.16296.1.S1_at

Participates

as a component of

Other forms of this molecule

CYBA [specific granule membrane]

CYBA [plasma membrane]

CYBA [tertiary granule membrane]

CYBA [endoplasmic reticulum membrane]

Inferred From

CYBA [phagocytic vesicle membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000051523

Ensembl

ENSSSCP00000055460, ENSSSCT00000052015, ENSSSCG00000031493

VGNC

87124

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