Reactome | H3C15 [nucleoplasm]

Cell Cycle (Sus scrofa)

- Cell Cycle, Mitotic (Sus scrofa)
  - M Phase (Sus scrofa)
    - Mitotic Prophase (Sus scrofa)
      - Condensation of Prophase Chromosomes (Sus scrofa)
        
        CDK1 phosphorylates PHF8 (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        H3K4me3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        H3K4me3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        CDK1 phosphorylates condensin II subunit NCAPD3 (Sus scrofa)
        
        Condensin II:Nucleosome with H4K20me1 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        H3K4me3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        H3K4me3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        Condensin II complex binds H4K20me1-containing nucleosomes (Sus scrofa)
        
        Condensin II:Nucleosome with H4K20me1 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        H3K4me3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        H3K4me3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        PHF8 demethylates histone H4K20me1 (Sus scrofa)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        H3K4me3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        H3K4me3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        PLK1 binds phosphorylated condensin II complex (Sus scrofa)
        
        Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        H3K4me3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        H3K4me3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        PLK1 hyperphosphorylates Condensin II complex (Sus scrofa)
        
        Hyperphosphorylated Condensin II:Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        H3K4me3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        H3K4me3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        SETD8 monomethylates histone H4 (Sus scrofa)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        H3K4me3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Sus scrofa)
        
        H3K4me2/3 [nucleoplasm] (Sus scrofa)
        
        H3K4me3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)

Chromatin organization (Sus scrofa)

- ATP-dependent chromatin remodelers (Sus scrofa)
  - CHD chromatin remodelers (Sus scrofa)
    - CHD1 and CHD2 subfamily (Sus scrofa)
      - CHD1 and CHD2 bind H3K4me3 nucleosomes (Sus scrofa)
        
        CHD1,CHD2:H3K4me3 chromatin [nucleoplasm] (Sus scrofa)
        
        chromatin with H3K4me3 nucleosomes [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        chromatin with H3K4me3 nucleosomes [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
      - CHD1:H3K4me3 interacts with post-initiation transcription complexes (Sus scrofa)
        
        CHD1:H3K4 nucleosome:FACT complex:U2 snRNP complex:PAF1C complex [nucleoplasm] (Sus scrofa)
        
        CHD1:H3K4me3 chromatin [nucleoplasm] (Sus scrofa)
        
        chromatin with H3K4me3 nucleosomes [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        CHD1:H3K4me3 chromatin [nucleoplasm] (Sus scrofa)
        
        chromatin with H3K4me3 nucleosomes [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
    - CHD3, CHD4, CHD5 subfamily (Sus scrofa)
      - NuRD complex assembly (Sus scrofa)
        
        Interaction of NuRD complexes with transcription factors (Sus scrofa)
        
        NuRD binds TCF19 at FBP1 gene (Sus scrofa)
        
        FBP1 gene:H3K4me3 nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        TCF19:NuRD:FBP1 gene:H3K4 nucleosome [nucleoplasm] (Sus scrofa)
        
        FBP1 gene:H3K4me3 nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        NuRD binds TCF19 at G6PC gene (Sus scrofa)
        
        G6PC gene:H3K4me3 nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        TCF19:NuRD:G6PC gene:H3K4 nucleosome [nucleoplasm] (Sus scrofa)
        
        G6PC gene:H3K4me3 nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        NuRD binds TCF19 at PCK1 gene (Sus scrofa)
        
        PCK1 gene:H3K4me3 nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        TCF19:NuRD:PCK1 gene:H3K4 nucleosome [nucleoplasm] (Sus scrofa)
        
        PCK1 gene:H3K4me3 nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
- Chromatin modifying enzymes (Sus scrofa)
  - HDMs demethylate histones (Sus scrofa)
    - KDM5A-D demethylate Me3K5-histone H3 (Sus scrofa)
      - Me3K5-histone H3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
  - PKMTs methylate histone lysines (Sus scrofa)
    - Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Sus scrofa)
      - Me3K5-histone H3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional regulation by RUNX1 (Sus scrofa)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Sus scrofa)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Sus scrofa)
        
        H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Sus scrofa)
        
        H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)
        
        H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Sus scrofa)
        
        H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Regulation of T cell activation by CD28 family (Sus scrofa)
    - Co-inhibition by PD-1 (Sus scrofa)
      - Regulation of PD-L1(CD274) expression (Sus scrofa)
        
        Regulation of PD-L1(CD274) transcription (Sus scrofa)
        
        Trimethylation of CD274 gene chromatin by MLL1/3 complex (Sus scrofa)
        
        MLL1,MLL3_complex:CD274 gene H3K4me3 chromatin [nucleoplasm] (Sus scrofa)
        
        CD274 gene H3K4me3 chromatin [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K4me3) [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by WNT (Sus scrofa)
  - TCF dependent signaling in response to WNT (Sus scrofa)
    - Formation of the beta-catenin:TCF transactivating complex (Sus scrofa)
      - MLL2 complex trimethylates H3K4 at the MYC gene (Sus scrofa)
        
        MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H2BK121ub and H3K4me3 [nucleoplasm] (Sus scrofa)
        
        H3K4me3 [nucleoplasm] (Sus scrofa)
        
        H3C15 [nucleoplasm] (Sus scrofa)