Reactome | RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm]

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional Regulation by TP53 (Sus scrofa)
      - TP53 Regulates Transcription of DNA Repair Genes (Sus scrofa)
        
        CCNK:CDK12 binds RNA Pol II at DNA repair genes (Sus scrofa)
        
        CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Sus scrofa)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Sus scrofa)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Sus scrofa)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Sus scrofa)
        
        CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Sus scrofa)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Sus scrofa)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
  - RNA Polymerase II Pre-transcription Events (Sus scrofa)
    - 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Sus scrofa)
      - Paused processive elongation complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
      - Processive elongation complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
    - 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Sus scrofa)
      - Processive elongation complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
    - Abortive termination of elongation after arrest (Sus scrofa)
      - Processive elongation complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
    - Elongating transcript encounters a lesion in the template (Sus scrofa)
      - Processive elongation complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
    - Resumption of elongation after recovery from pausing (Sus scrofa)
      - Paused processive elongation complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
      - Processive elongation complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
    - TFIIS-mediated recovery of elongation from arrest (Sus scrofa)
      - Processive elongation complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
  - RNA Polymerase II Transcription Elongation (Sus scrofa)
    - Addition of nucleotides leads to transcript elongation (Sus scrofa)
      - Elongation complex [nucleoplasm] (Sus scrofa)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
      - Processive elongation complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
    - Formation of RNA Pol II elongation complex (Sus scrofa)
      - Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Sus scrofa)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
      - Recruitment of elongation factors to form elongation complex (Sus scrofa)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        Elongation complex [nucleoplasm] (Sus scrofa)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
    - Pol II elongation complex moves on the template as transcript elongates (Sus scrofa)
      - Elongation complex prior to separation [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
      - Processive elongation complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
    - Separation of elongating transcript from template (Sus scrofa)
      - Elongation complex prior to separation [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
      - Elongation complex with separated and uncleaved transcript [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)

Metabolism of RNA (Sus scrofa)

- Processing of Capped Intron-Containing Pre-mRNA (Sus scrofa)
  - Formation of pre-mRNPs (Sus scrofa)
    - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
      - RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
      - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
  - Internal Methylation of mRNA (Sus scrofa)
    - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
      - RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
  - mRNA Splicing (Sus scrofa)
    - mRNA Splicing - Major Pathway (Sus scrofa)
      - Formation of the Spliceosomal Bact complex (Sus scrofa)
        
        Spliceosomal B complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        Spliceosomal Bact complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
      - Formation of the Spliceosomal C* complex (Sus scrofa)
        
        Spliceosomal C complex [nucleoplasm] (Sus scrofa)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        Spliceosomal C* complex [nucleoplasm] (Sus scrofa)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
      - Formation of the Spliceosomal E complex (Sus scrofa)
        
        Spliceosomal E complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
      - Formation of the Spliceosomal P complex and exon ligation (Sus scrofa)
        
        Spliceosomal C* complex [nucleoplasm] (Sus scrofa)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        Spliceosomal P complex [nucleoplasm] (Sus scrofa)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
    - mRNA Splicing - Minor Pathway (Sus scrofa)
      - ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Sus scrofa)
        
        ATAC C Complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        post exon ligation complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
      - ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Sus scrofa)
        
        ATAC C Complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
      - Formation of AT-AC B Complex (Sus scrofa)
        
        ATAC A Complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        ATAC B Complex [nucleoplasm] (Sus scrofa)
        
        ATAC A Complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
      - Formation of AT-AC C complex (Sus scrofa)
        
        ATAC B Complex [nucleoplasm] (Sus scrofa)
        
        ATAC A Complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        ATAC C Complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Nuclear Receptors (Sus scrofa)
  - ESR-mediated signaling (Sus scrofa)
    - Estrogen-dependent gene expression (Sus scrofa)
      - p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Sus scrofa)
        
        MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)