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CBL [cytosol]
Stable Identifier
R-SSC-112199
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
CBL, A0A286ZQE1
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
FLT3 Signaling (Sus scrofa)
Negative regulation of FLT3 (Sus scrofa)
Active FLT3 binds to CBL (Sus scrofa)
CBL [cytosol] (Sus scrofa)
active FLT3:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
FLT3 phosphorylates CBL (Sus scrofa)
active FLT3:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Sus scrofa)
Regulation of signaling by CBL (Sus scrofa)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Sus scrofa)
CBL [cytosol] (Sus scrofa)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Interleukin-6 family signaling (Sus scrofa)
Interleukin-6 signaling (Sus scrofa)
PTPN11 binds CBL (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by Non-Receptor Tyrosine Kinases (Sus scrofa)
Signaling by PTK6 (Sus scrofa)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Sus scrofa)
PTK6 phosphorylates CBL (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by EGFR (Sus scrofa)
EGFR downregulation (Sus scrofa)
Binding of CBL to EGFR (Sus scrofa)
CBL [cytosol] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
CBL binds and ubiquitinates phosphorylated Sprouty (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
CBL binds to GRB2 (Sus scrofa)
CBL [cytosol] (Sus scrofa)
CBL:GRB2 [cytosol] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Sus scrofa)
CBL:GRB2 [cytosol] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
CBL ubiquitinates Sprouty (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
CBL-mediated ubiquitination of CIN85 (Sus scrofa)
CBL [cytosol] (Sus scrofa)
CDC42:GTP binds CBL:Beta-Pix (Sus scrofa)
CBL [cytosol] (Sus scrofa)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Localization of CBL:GRB2 to the membrane (Sus scrofa)
CBL:GRB2 [cytosol] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Sus scrofa)
CBL:GRB2 [cytosol] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Phosphorylation of CBL (EGFR:CBL) (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Sus scrofa)
CBL:GRB2 [cytosol] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Sprouty lures CBL away from EGFR (Sus scrofa)
CBL [cytosol] (Sus scrofa)
CBL:SPRY1/2 [cytosol] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Signaling by FGFR (Sus scrofa)
Signaling by FGFR1 (Sus scrofa)
Negative regulation of FGFR1 signaling (Sus scrofa)
Spry regulation of FGF signaling (Sus scrofa)
CBL dissociates from ubiquitinated p-SPRY2 (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Phosphorylated SPRY2 is ubiquitinated by CBL (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
SPRY2 binds CBL (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Signaling by FGFR2 (Sus scrofa)
Negative regulation of FGFR2 signaling (Sus scrofa)
Spry regulation of FGF signaling (Sus scrofa)
CBL dissociates from ubiquitinated p-SPRY2 (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Phosphorylated SPRY2 is ubiquitinated by CBL (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
SPRY2 binds CBL (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Signaling by FGFR3 (Sus scrofa)
Negative regulation of FGFR3 signaling (Sus scrofa)
Spry regulation of FGF signaling (Sus scrofa)
CBL dissociates from ubiquitinated p-SPRY2 (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Phosphorylated SPRY2 is ubiquitinated by CBL (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
SPRY2 binds CBL (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Signaling by FGFR4 (Sus scrofa)
Negative regulation of FGFR4 signaling (Sus scrofa)
Spry regulation of FGF signaling (Sus scrofa)
CBL dissociates from ubiquitinated p-SPRY2 (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Phosphorylated SPRY2 is ubiquitinated by CBL (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
SPRY2 binds CBL (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Signaling by MET (Sus scrofa)
Negative regulation of MET activity (Sus scrofa)
CBL binds MET (Sus scrofa)
CBL:GRB2,CBL [cytosol] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
CBL:GRB2 [cytosol] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Sus scrofa)
CBL:GRB2 [cytosol] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
MET phosphorylates CBL (Sus scrofa)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Sus scrofa)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Sus scrofa)
CBL:GRB2 [cytosol] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Signaling by SCF-KIT (Sus scrofa)
Regulation of KIT signaling (Sus scrofa)
Recruitment of CBL to KIT (Sus scrofa)
CBL [cytosol] (Sus scrofa)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
Signaling by TGFB family members (Sus scrofa)
Signaling by TGF-beta Receptor Complex (Sus scrofa)
TGF-beta receptor signaling activates SMADs (Sus scrofa)
CBL binds TGFBR2 (Sus scrofa)
CBL [cytosol] (Sus scrofa)
TGFBR2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
CBL neddylates TGFBR2 (Sus scrofa)
CBL [cytosol] (Sus scrofa)
TGFBR2:CBL [plasma membrane] (Sus scrofa)
CBL [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A286ZQE1
Gene Names
CBL
Reference Genes
BioGPS Gene:100518854 CBL
ENSEMBL:ENSSSCG00000015115.5
KEGG Gene (Sus scrofa):100518854 CBL
Monarch:100518854 CBL
NCBI Gene:100518854 CBL
Reference Transcript
RefSeq:XM_003129932.3 CBL
Other Identifiers
100518854
GO:0001784
GO:0003824
GO:0004842
GO:0005509
GO:0005794
GO:0005829
GO:0005886
GO:0005929
GO:0006511
GO:0007165
GO:0007166
GO:0008152
GO:0012501
GO:0016192
GO:0016567
GO:0016600
GO:0016740
GO:0017124
GO:0023051
GO:0023052
GO:0030163
GO:0030971
GO:0032487
GO:0036211
GO:0042059
GO:0043066
GO:0043226
GO:0045121
GO:0046872
GO:0046875
GO:0048260
GO:0051897
GO:0061630
GO:0070086
GO:0140096
GO:2000583
Ssc.14185.1.A1_at
Ssc.1914.1.S1_at
Ssc.24231.1.S1_at
Ssc.30540.1.A1_at
Participates
as an input of
Active FLT3 binds to CBL (Sus scrofa)
PTPN11 binds CBL (Sus scrofa)
Sprouty lures CBL away from EGFR (Sus scrofa)
CDC42:GTP binds CBL:Beta-Pix (Sus scrofa)
Binding of CBL to EGFR (Sus scrofa)
PTK6 phosphorylates CBL (Sus scrofa)
SPRY2 binds CBL (Sus scrofa)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Sus scrofa)
CBL binds to GRB2 (Sus scrofa)
Recruitment of CBL to KIT (Sus scrofa)
CBL binds TGFBR2 (Sus scrofa)
as a component of
active FLT3:CBL [plasma membrane] (Sus scrofa)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Sus scrofa)
CBL:SPRY1/2 [cytosol] (Sus scrofa)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Sus scrofa)
CBL:GRB2 [cytosol] (Sus scrofa)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Sus scrofa)
TGFBR2:CBL [plasma membrane] (Sus scrofa)
as an output of
CBL dissociates from ubiquitinated p-SPRY2 (Sus scrofa)
CBL neddylates TGFBR2 (Sus scrofa)
as a candidate of
CBL:GRB2,CBL [cytosol] (Sus scrofa)
Other forms of this molecule
phospho-CBL [plasma membrane]
phospho-CBL [cytosol]
phospho-CBL [cytosol]
phospho-CBL [cytosol]
phospho-CBL [cytosol]
Inferred From
CBL [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_003129980.1
OpenTargets
ENSG00000110395
Ensembl
ENSSSCT00000040411
,
ENSSSCG00000015115
,
ENSSSCP00000033673
VGNC
86222
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