Reactome | upf2 [cytosol]

upf2 [cytosol]

Stable Identifier

R-SPO-927799

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

cytosol

Synonyms

UPF2, O13824

Locations in the PathwayBrowser

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Metabolism of RNA (Schizosaccharomyces pombe)

- Nonsense-Mediated Decay (NMD) (Schizosaccharomyces pombe)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Schizosaccharomyces pombe)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Schizosaccharomyces pombe)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Schizosaccharomyces pombe)
        
        upf2 [cytosol] (Schizosaccharomyces pombe)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Schizosaccharomyces pombe)
        
        upf2 [cytosol] (Schizosaccharomyces pombe)
    - SMG6 hydrolyzes mRNA with premature termination codon (Schizosaccharomyces pombe)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Schizosaccharomyces pombe)
        
        upf2 [cytosol] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:O13824

Gene Names

upf2

Reference Genes

BioGPS Gene:2542147 upf2

ENSEMBL:SPAC19A8.08

KEGG:spo:2542147 upf2

Monarch:2542147 upf2

NCBI Gene:2542147 upf2

PomBase:SPAC19A8.08

UCSC:O13824 upf2

Reference Transcript

RefSeq:NM_001019213.2 upf2

Participates

as a component of

Exon Junction:UPF2:UPF3 Complex [cytosol] (Schizosaccharomyces pombe)

Inferred From

UPF2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_593784.1

PRO

O13824

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