Reactome | rpl2002 [cytosol]

rpl2002 [cytosol]

Stable Identifier

R-SPO-72422-2

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

cytosol

Synonyms

RPL18A, P0CT69

Locations in the PathwayBrowser

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Metabolism of RNA (Schizosaccharomyces pombe)

- Nonsense-Mediated Decay (NMD) (Schizosaccharomyces pombe)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Schizosaccharomyces pombe)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Schizosaccharomyces pombe)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL18A [cytosol] (Schizosaccharomyces pombe)
        
        rpl2002 [cytosol] (Schizosaccharomyces pombe)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL18A [cytosol] (Schizosaccharomyces pombe)
        
        rpl2002 [cytosol] (Schizosaccharomyces pombe)
    - SMG6 hydrolyzes mRNA with premature termination codon (Schizosaccharomyces pombe)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL18A [cytosol] (Schizosaccharomyces pombe)
        
        rpl2002 [cytosol] (Schizosaccharomyces pombe)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Schizosaccharomyces pombe)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Schizosaccharomyces pombe)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL18A [cytosol] (Schizosaccharomyces pombe)
        
        rpl2002 [cytosol] (Schizosaccharomyces pombe)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL18A [cytosol] (Schizosaccharomyces pombe)
        
        rpl2002 [cytosol] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:P0CT69

Gene Names

rpl2002

Reference Genes

BioGPS Gene:2542093 rpl2002

BioGPS Gene:2542725 rpl2002

ENSEMBL:SPAC26A3.04

GeneDB:SPAC26A3.04

KEGG Gene (Schizosaccharomyces pombe):SPAC26A3.04 rpl2002

KEGG Gene (Schizosaccharomyces pombe):SPAC3A12.10 rpl2002

Monarch:2542093 rpl2002

Monarch:2542725 rpl2002

NCBI Gene:2542093 rpl2002

NCBI Gene:2542725 rpl2002

Reference Transcript

Participates

as a member of

Homologues of RPL18A [cytosol] (Schizosaccharomyces pombe)

Inferred From

RPL18A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_593336.1, NP_594147.1

PRO

P0CT69

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