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CDC6 [nucleoplasm]
Stable Identifier
R-SPO-68542
Type
Protein [EntityWithAccessionedSequence]
Species
Schizosaccharomyces pombe
Compartment
nucleoplasm
Synonyms
P41411
Locations in the PathwayBrowser
Expand all
Cell Cycle (Schizosaccharomyces pombe)
Cell Cycle Checkpoints (Schizosaccharomyces pombe)
G2/M Checkpoints (Schizosaccharomyces pombe)
Activation of ATR in response to replication stress (Schizosaccharomyces pombe)
Loading of claspin onto DNA during replication origin firing (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
Cell Cycle, Mitotic (Schizosaccharomyces pombe)
Mitotic G1 phase and G1/S transition (Schizosaccharomyces pombe)
G1/S Transition (Schizosaccharomyces pombe)
Activation of the pre-replicative complex (Schizosaccharomyces pombe)
CDK and DDK associate with the Mcm10:pre-replicative complex (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
Cdc45 associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
Cdt1 is displaced from the pre-replicative complex. (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
DNA polymerase alpha:primase binds at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
DNA polymerase epsilon binds at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Schizosaccharomyces pombe)
MCM10:pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
S Phase (Schizosaccharomyces pombe)
Synthesis of DNA (Schizosaccharomyces pombe)
Switching of origins to a post-replicative state (Schizosaccharomyces pombe)
CDK-mediated phosphorylation and removal of Cdc6 (Schizosaccharomyces pombe)
Cdc6 protein is phosphorylated by CDK (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
Orc1 removal from chromatin (Schizosaccharomyces pombe)
Orc1 is phosphorylated by cyclin A/CDK2 (Schizosaccharomyces pombe)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
DNA Replication (Schizosaccharomyces pombe)
DNA Replication Pre-Initiation (Schizosaccharomyces pombe)
Activation of the pre-replicative complex (Schizosaccharomyces pombe)
CDK and DDK associate with the Mcm10:pre-replicative complex (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
Cdc45 associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
Cdt1 is displaced from the pre-replicative complex. (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
DNA polymerase alpha:primase binds at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
DNA polymerase epsilon binds at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Schizosaccharomyces pombe)
MCM10:pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
Assembly of the pre-replicative complex (Schizosaccharomyces pombe)
CDC6 association with the ORC:origin complex (Schizosaccharomyces pombe)
CDC6 association with ORC(1-6) at replication origins (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
Synthesis of DNA (Schizosaccharomyces pombe)
Switching of origins to a post-replicative state (Schizosaccharomyces pombe)
CDK-mediated phosphorylation and removal of Cdc6 (Schizosaccharomyces pombe)
Cdc6 protein is phosphorylated by CDK (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
Orc1 removal from chromatin (Schizosaccharomyces pombe)
Orc1 is phosphorylated by cyclin A/CDK2 (Schizosaccharomyces pombe)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6 [nucleoplasm] (Schizosaccharomyces pombe)
External Reference Information
External Reference
UniProt:P41411
Reference Genes
BioGPS Gene:2540013
ENSEMBL:SPBC14C8.07c
GeneDB:SPBC14C8.07c
KEGG Gene (Schizosaccharomyces pombe):SPBC14C8.07c
Monarch:2540013
NCBI Gene:2540013
Reference Transcript
RefSeq:NM_001021818.2
Participates
as an input of
Cdc6 protein is phosphorylated by CDK (Schizosaccharomyces pombe)
CDC6 association with ORC(1-6) at replication origins (Schizosaccharomyces pombe)
as a component of
pre-replicative complex (Orc1-minus) [nucleoplasm] (Schizosaccharomyces pombe)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
Other forms of this molecule
CDC6 [cytosol]
phospho-p-CDC6 [cytosol]
phospho-p-CDC6 [nucleoplasm]
Inferred From
CDC6 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_595910.1
PRO
P41411
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P87060 POP1
0.688
3
UniProt:O14170 POP2
0.564
3
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