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What is Reactome ?
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ORC:origin of replication [nucleoplasm]
Stable Identifier
R-SPO-68540
Type
Complex
Species
Schizosaccharomyces pombe
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Schizosaccharomyces pombe)
Cell Cycle Checkpoints (Schizosaccharomyces pombe)
G2/M Checkpoints (Schizosaccharomyces pombe)
Activation of ATR in response to replication stress (Schizosaccharomyces pombe)
Loading of claspin onto DNA during replication origin firing (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
Cell Cycle, Mitotic (Schizosaccharomyces pombe)
Mitotic G1 phase and G1/S transition (Schizosaccharomyces pombe)
G1/S Transition (Schizosaccharomyces pombe)
Activation of the pre-replicative complex (Schizosaccharomyces pombe)
CDK and DDK associate with the Mcm10:pre-replicative complex (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
Cdc45 associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
Cdt1 is displaced from the pre-replicative complex. (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
DNA polymerase alpha:primase binds at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
DNA polymerase epsilon binds at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Schizosaccharomyces pombe)
MCM10:pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
S Phase (Schizosaccharomyces pombe)
Synthesis of DNA (Schizosaccharomyces pombe)
Switching of origins to a post-replicative state (Schizosaccharomyces pombe)
Orc1 removal from chromatin (Schizosaccharomyces pombe)
Orc1 is phosphorylated by cyclin A/CDK2 (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
DNA Replication (Schizosaccharomyces pombe)
DNA Replication Pre-Initiation (Schizosaccharomyces pombe)
Activation of the pre-replicative complex (Schizosaccharomyces pombe)
CDK and DDK associate with the Mcm10:pre-replicative complex (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
Cdc45 associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
Cdt1 is displaced from the pre-replicative complex. (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
DNA polymerase alpha:primase binds at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
DNA polymerase epsilon binds at the origin (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Schizosaccharomyces pombe)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
MCM10:active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
active pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Schizosaccharomyces pombe)
MCM10:pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
Synthesis of DNA (Schizosaccharomyces pombe)
Switching of origins to a post-replicative state (Schizosaccharomyces pombe)
Orc1 removal from chromatin (Schizosaccharomyces pombe)
Orc1 is phosphorylated by cyclin A/CDK2 (Schizosaccharomyces pombe)
pre-replicative complex [nucleoplasm] (Schizosaccharomyces pombe)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
ORC:origin of replication [nucleoplasm] (Schizosaccharomyces pombe)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
Ghost homologue of origin of replication [nucleoplasm]
(Schizosaccharomyces pombe)
ORC1 [nucleoplasm]
(Schizosaccharomyces pombe)
Orc2 associated with MCM8 [nucleoplasm]
(Schizosaccharomyces pombe)
orc3 [nucleoplasm]
(Schizosaccharomyces pombe)
ORC4 [nucleoplasm]
(Schizosaccharomyces pombe)
ORC5 [nucleoplasm]
(Schizosaccharomyces pombe)
phospho-orc6 [nucleoplasm]
(Schizosaccharomyces pombe)
Participates
as a component of
CDC6:ORC:origin complex [nucleoplasm] (Schizosaccharomyces pombe)
Inferred From
ORC:origin of replication [nucleoplasm]
(Homo sapiens)
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