Reactome | par1 [cytosol]

par1 [cytosol]

Stable Identifier

R-SPO-535469-2

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

cytosol

Synonyms

PPP2R5B, Q10428

Locations in the PathwayBrowser

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Immune System (Schizosaccharomyces pombe)

- Adaptive Immune System (Schizosaccharomyces pombe)
  - Regulation of T cell activation by CD28 family (Schizosaccharomyces pombe)
    - Co-inhibition by CTLA4 (Schizosaccharomyces pombe)
      - Dephosphorylation of AKT by PP2A (Schizosaccharomyces pombe)
        
        PP2A [cytosol] (Schizosaccharomyces pombe)
        
        PP2A regulatory subunit B56 [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of PPP2R5B [cytosol] (Schizosaccharomyces pombe)
        
        par1 [cytosol] (Schizosaccharomyces pombe)

Signal Transduction (Schizosaccharomyces pombe)

- Intracellular signaling by second messengers (Schizosaccharomyces pombe)
  - PIP3 activates AKT signaling (Schizosaccharomyces pombe)
    - Negative regulation of the PI3K/AKT network (Schizosaccharomyces pombe)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Schizosaccharomyces pombe)
        
        AKT1 dephosphorylation by PP2A-B56-beta,gamma (Schizosaccharomyces pombe)
        
        PP2A-B56-beta,gamma [cytosol] (Schizosaccharomyces pombe)
        
        PPP2R5B,PPP2R5C [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of PPP2R5B [cytosol] (Schizosaccharomyces pombe)
        
        par1 [cytosol] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:Q10428

Gene Names

par1

Reference Genes

BioGPS Gene:2539379 par1

ENSEMBL:SPCC188.02

KEGG:spo:2539379 par1

Monarch:2539379 par1

NCBI Gene:2539379 par1

PomBase:SPCC188.02

UCSC:Q10428 par1

Reference Transcript

RefSeq:NM_001023196.2 par1

Participates

as a member of

Homologues of PPP2R5B [cytosol] (Schizosaccharomyces pombe)

Other forms of this molecule

phospho-par1 [cytosol]

par1 [nucleoplasm]

par1 [cytosol]

Inferred From

PPP2R5B [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_588206.1

PRO

Q10428

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13681	3	PPP1CA [nucleoplasm] (R-SPO-61995) PPP1CB [nucleoplasm] (R-SPO-62003) PPP1CC [cytosol] (R-SPO-163443)	0.641	12

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