Reactome | NCBP2 [nucleoplasm]

NCBP2 [nucleoplasm]

Stable Identifier

R-SPO-51463

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

nucleoplasm

Synonyms

Q9P383

Locations in the PathwayBrowser

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Metabolism of RNA (Schizosaccharomyces pombe)

- Nuclear RNA decay (Schizosaccharomyces pombe)
  - MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome (Schizosaccharomyces pombe)
    - PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Schizosaccharomyces pombe)
      - CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        CBCA complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
    - PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PAPBN1:RNA exosome [nucleoplasm] (Schizosaccharomyces pombe)
      - PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        CBCA complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
- Processing of Capped Intron-Containing Pre-mRNA (Schizosaccharomyces pombe)
  - Formation of pre-mRNPs (Schizosaccharomyces pombe)
    - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Schizosaccharomyces pombe)
      - Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Schizosaccharomyces pombe)
      - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
  - Transport of Mature Transcript to Cytoplasm (Schizosaccharomyces pombe)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Schizosaccharomyces pombe)
      - Transport of the export-competent mRNP complex through the NPC (Schizosaccharomyces pombe)
        
        NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
    - Transport of Mature mRNAs Derived from Intronless Transcripts (Schizosaccharomyces pombe)
      - Transport of Mature mRNA Derived from an Intronless Transcript (Schizosaccharomyces pombe)
        
        Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Schizosaccharomyces pombe)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Mature intronless derived mRNA complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
      - Transport of the SLBP independent Mature mRNA (Schizosaccharomyces pombe)
        
        Docking of Mature Histone mRNA complex:TAP at the NPC (Schizosaccharomyces pombe)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Mature intronless transcript derived Histone pre-mRNA:CBC complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
  - mRNA 3'-end processing (Schizosaccharomyces pombe)
    - mRNA Polyadenylation (Schizosaccharomyces pombe)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Schizosaccharomyces pombe)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Schizosaccharomyces pombe)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Schizosaccharomyces pombe)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
      - PP1 dephosphorylates RNA Pol II (Schizosaccharomyces pombe)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Schizosaccharomyces pombe)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Schizosaccharomyces pombe)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated pre-mRNA:CBC Complex (RNA Pol II dephosphorylated on Ser5) [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
  - mRNA Splicing (Schizosaccharomyces pombe)
    - mRNA Splicing - Major Pathway (Schizosaccharomyces pombe)
      - Formation of the Spliceosomal C complex containing intron lariat (Schizosaccharomyces pombe)
        
        Spliceosomal B* complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped, methylated, polyadenylated pre-mRNA:CBC Complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Spliceosomal C complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        mRNA 5' exon:CBC complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
- Processing of Capped Intronless Pre-mRNA (Schizosaccharomyces pombe)
  - Processing of Intronless Pre-mRNAs (Schizosaccharomyces pombe)
    - Recognition of AAUAAA sequence by CPSF (Schizosaccharomyces pombe)
      - CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        capped intronless pre-mRNA:CBC complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
      - capped intronless pre-mRNA:CBC complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
- mRNA Capping (Schizosaccharomyces pombe)
  - Formation of cap binding complex (CBC) (Schizosaccharomyces pombe)
    - Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
      - NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
    - NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
  - Recognition and binding of the mRNA cap by the cap-binding complex (Schizosaccharomyces pombe)
    - Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
      - NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)
    - capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Schizosaccharomyces pombe)
      - Cap Binding Complex (CBC) [nucleoplasm] (Schizosaccharomyces pombe)
        
        NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:Q9P383

Reference Genes

BioGPS Gene:2539791

ENSEMBL:SPBC13A2.01c

KEGG:spo:2539791

Monarch:2539791

NCBI Gene:2539791

PomBase:SPBC13A2.01c

UCSC:Q9P383

Reference Transcript

RefSeq:NM_001022333.2

Participates

as a component of

as an input of

Formation of cap binding complex (CBC) (Schizosaccharomyces pombe)

Other forms of this molecule

NCBP2 [cytosol]

Inferred From

NCBP2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_596414.1

PRO

Q9P383

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