Reactome | HSPA8 [nucleoplasm]

HSPA8 [nucleoplasm]

Stable Identifier

R-SPO-5082380-4

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

nucleoplasm

Synonyms

Q10284

Locations in the PathwayBrowser

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Cellular responses to stimuli (Schizosaccharomyces pombe)

- Cellular responses to stress (Schizosaccharomyces pombe)
  - Cellular response to heat stress (Schizosaccharomyces pombe)
    - HSF1-dependent transactivation (Schizosaccharomyces pombe)
      - Attenuation phase (Schizosaccharomyces pombe)
        
        HSP70:DNAJB1 binds HSF1 (Schizosaccharomyces pombe)
        
        HSP70:DNAJB1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA (HSP70) proteins [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSP70:DNAJB1:HSF1 trimer:target gene [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSP70:DNAJB1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA (HSP70) proteins [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
      - HSF1-mediated gene expression (Schizosaccharomyces pombe)
        
        Heat shock inducible proteins [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
    - Regulation of HSF1-mediated heat shock response (Schizosaccharomyces pombe)
      - HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Schizosaccharomyces pombe)
        
        HSP70s:ADP [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA8:ADP [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Hikeshi:HSP70s:ATP [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSP70s:ATP [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA8:ATP [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
      - NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Schizosaccharomyces pombe)
        
        Hikeshi:HSP70s:ATP [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSP70s:ATP [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA8:ATP [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
      - SIRT1 binds to HSF1 (Schizosaccharomyces pombe)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSP70:DNAJB1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA (HSP70) proteins [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSP70:DNAJB1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA (HSP70) proteins [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
      - SIRT1 deacetylates HSF1 (Schizosaccharomyces pombe)
        
        HSP70:DNAJB1:HSF1 trimer:target gene [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSP70:DNAJB1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA (HSP70) proteins [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSP70:DNAJB1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA (HSP70) proteins [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)

Metabolism of RNA (Schizosaccharomyces pombe)

- Processing of Capped Intron-Containing Pre-mRNA (Schizosaccharomyces pombe)
  - mRNA Splicing (Schizosaccharomyces pombe)
    - mRNA Splicing - Major Pathway (Schizosaccharomyces pombe)
      - Formation of the Spliceosomal C complex containing intron lariat (Schizosaccharomyces pombe)
        
        Spliceosomal B* complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        PRP19-CDC5L complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Spliceosomal C complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        PRP19-CDC5L complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:Q10284

Reference Genes

BioGPS Gene:2540199

ENSEMBL:SPBC1709.05

KEGG:spo:2540199

Monarch:2540199

NCBI Gene:2540199

PomBase:SPBC1709.05

UCSC:Q10284

Reference Transcript

RefSeq:NM_001021346.2

Participates

as a member of

Homologues of HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)

Other forms of this molecule

Me3K561-HSPA8 [nucleoplasm]

HSPA7 [cytosol]

HSPA6 [cytosol]

HSPA13 [cytosol]

HSPA14 [cytosol]

HSPA7 [nucleoplasm]

HSPA13 [nucleoplasm]

HSPA6 [nucleoplasm]

HSPA14 [nucleoplasm]

HSPA1L [nucleoplasm]

HSPA2 [nucleoplasm]

HSPA6 [secretory granule lumen]

HSPA8 [secretory granule lumen]

HSPA8 [extracellular region]

HSPA6 [extracellular region]

HSPA8 [ficolin-1-rich granule lumen]

HSPA6 [ficolin-1-rich granule lumen]

HSPA2 [cytosol]

HSPA1L [cytosol]

HSPA8 [cytosol]

Inferred From

HSPA8 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_595438.1

IntEnz

3.6.4.10

PRO

Q10284

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