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phospho-p-T309,S474-AKT2 [cytosol]
Stable Identifier
R-SPO-202062
Type
Protein [EntityWithAccessionedSequence]
Species
Schizosaccharomyces pombe
Compartment
cytosol
Synonyms
P50530
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Schizosaccharomyces pombe)
RNA Polymerase II Transcription (Schizosaccharomyces pombe)
Generic Transcription Pathway (Schizosaccharomyces pombe)
Transcriptional Regulation by TP53 (Schizosaccharomyces pombe)
TP53 Regulates Metabolic Genes (Schizosaccharomyces pombe)
AKT phosphorylates TSC2, inhibiting it (Schizosaccharomyces pombe)
p-T,p-S-AKT [cytosol] (Schizosaccharomyces pombe)
phospho-p-T309,S474-AKT2 [cytosol] (Schizosaccharomyces pombe)
Immune System (Schizosaccharomyces pombe)
Adaptive Immune System (Schizosaccharomyces pombe)
Regulation of T cell activation by CD28 family (Schizosaccharomyces pombe)
Co-inhibition by CTLA4 (Schizosaccharomyces pombe)
Dephosphorylation of AKT by PP2A (Schizosaccharomyces pombe)
p-T,p-S-AKT [cytosol] (Schizosaccharomyces pombe)
phospho-p-T309,S474-AKT2 [cytosol] (Schizosaccharomyces pombe)
Signal Transduction (Schizosaccharomyces pombe)
Intracellular signaling by second messengers (Schizosaccharomyces pombe)
PIP3 activates AKT signaling (Schizosaccharomyces pombe)
AKT phosphorylates targets in the cytosol (Schizosaccharomyces pombe)
AKT phosphorylates MKRN1 (Schizosaccharomyces pombe)
p-T,p-S-AKT [cytosol] (Schizosaccharomyces pombe)
phospho-p-T309,S474-AKT2 [cytosol] (Schizosaccharomyces pombe)
AKT phosphorylates TSC2, inhibiting it (Schizosaccharomyces pombe)
p-T,p-S-AKT [cytosol] (Schizosaccharomyces pombe)
phospho-p-T309,S474-AKT2 [cytosol] (Schizosaccharomyces pombe)
Negative regulation of the PI3K/AKT network (Schizosaccharomyces pombe)
PHLPP dephosphorylates S473 in AKT (Schizosaccharomyces pombe)
p-T,p-S-AKT [cytosol] (Schizosaccharomyces pombe)
phospho-p-T309,S474-AKT2 [cytosol] (Schizosaccharomyces pombe)
PTEN Regulation (Schizosaccharomyces pombe)
Regulation of PTEN stability and activity (Schizosaccharomyces pombe)
AKT phosphorylates MKRN1 (Schizosaccharomyces pombe)
p-T,p-S-AKT [cytosol] (Schizosaccharomyces pombe)
phospho-p-T309,S474-AKT2 [cytosol] (Schizosaccharomyces pombe)
MTOR signalling (Schizosaccharomyces pombe)
Inhibition of TSC complex formation by AKT (PKB) (Schizosaccharomyces pombe)
Phosphorylation of TSC2 by AKT (PKB) (Schizosaccharomyces pombe)
p-T,p-S-AKT [cytosol] (Schizosaccharomyces pombe)
phospho-p-T309,S474-AKT2 [cytosol] (Schizosaccharomyces pombe)
Phosphorylation of complexed TSC2 by PKB (Schizosaccharomyces pombe)
p-T,p-S-AKT [cytosol] (Schizosaccharomyces pombe)
phospho-p-T309,S474-AKT2 [cytosol] (Schizosaccharomyces pombe)
Signaling by Receptor Tyrosine Kinases (Schizosaccharomyces pombe)
Signaling by Insulin receptor (Schizosaccharomyces pombe)
Insulin receptor signalling cascade (Schizosaccharomyces pombe)
IRS-mediated signalling (Schizosaccharomyces pombe)
PI3K Cascade (Schizosaccharomyces pombe)
Activation of AKT2 (Schizosaccharomyces pombe)
PDPK1 phosphorylates AKT2 (Schizosaccharomyces pombe)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
phospho-p-T309,S474-AKT2 [cytosol] (Schizosaccharomyces pombe)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Schizosaccharomyces pombe)
IGF1R signaling cascade (Schizosaccharomyces pombe)
IRS-related events triggered by IGF1R (Schizosaccharomyces pombe)
IRS-mediated signalling (Schizosaccharomyces pombe)
PI3K Cascade (Schizosaccharomyces pombe)
Activation of AKT2 (Schizosaccharomyces pombe)
PDPK1 phosphorylates AKT2 (Schizosaccharomyces pombe)
p-T309,S474-AKT2:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
phospho-p-T309,S474-AKT2 [cytosol] (Schizosaccharomyces pombe)
External Reference Information
External Reference
UniProt:P50530
Reference Genes
BioGPS Gene:2542492
ENSEMBL:SPAC1B9.02c
KEGG:spo:2542492
Monarch:2542492
NCBI Gene:2542492
PomBase:SPAC1B9.02c
UCSC:P50530
Reference Transcript
RefSeq:NM_001019184.2
Participates
as a member of
p-T,p-S-AKT [cytosol] (Schizosaccharomyces pombe)
as a component of
p-T309,S474-AKT2:PIP3 [plasma membrane] (Schizosaccharomyces pombe)
as a candidate of
p-T,p-S-AKT [cytosol] (Schizosaccharomyces pombe)
Other forms of this molecule
phospho-p-S473-AKT1 [cytosol]
phospho-p-T308,S473-AKT1 [plasma membrane]
phospho-p-T308-AKT1 [cytosol]
phospho-p-T305-AKT3 [cytosol]
phospho-p-T309-AKT2 [cytosol]
SGK1 [cytosol]
phospho-p-S422-SGK1 [cytosol]
phospho-p-T256,S422-SGK1 [cytosol]
phospho-p-T256,S422-SGK1 [nucleoplasm]
AKT1 [cytosol]
AKT3 [cytosol]
AKT2 [cytosol]
AKT1 [plasma membrane]
AKT3 [plasma membrane]
AKT2 [plasma membrane]
phospho-p-S473-AKT1 [plasma membrane]
phospho-p-S472-AKT3 [plasma membrane]
phospho-p-S474-AKT2 [plasma membrane]
phospho-p-T308,S473-AKT1 [cytosol]
phospho-p-T305,S472-AKT3 [cytosol]
phospho-p-T308,S473-AKT1 [nucleoplasm]
phospho-p-T305,S472-AKT3 [nucleoplasm]
phospho-p-T309,S474-AKT2 [nucleoplasm]
Inferred From
p-T309,S474-AKT2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 309 (in Homo sapiens)
Coordinate
309
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 474 (in Homo sapiens)
Coordinate
474
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_593754.1
PRO
P50530
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