Reactome | p-p38 MAPK alpha/beta [nucleoplasm]

Cell Cycle (Schizosaccharomyces pombe)

- Cell Cycle Checkpoints (Schizosaccharomyces pombe)
  - G1/S DNA Damage Checkpoints (Schizosaccharomyces pombe)
    - p53-Independent G1/S DNA Damage Checkpoint (Schizosaccharomyces pombe)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Schizosaccharomyces pombe)
        
        Phosphorylation of CDC25A by p38 MAPK (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)

Immune System (Schizosaccharomyces pombe)

- Cytokine Signaling in Immune system (Schizosaccharomyces pombe)
  - Signaling by Interleukins (Schizosaccharomyces pombe)
    - Interleukin-17 signaling (Schizosaccharomyces pombe)
      - MAP kinase activation (Schizosaccharomyces pombe)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
        
        Activation of the AP-1 family of transcription factors (Schizosaccharomyces pombe)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
        
        ERK/MAPK targets (Schizosaccharomyces pombe)
        
        p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
- Innate Immune System (Schizosaccharomyces pombe)
  - Toll-like Receptor Cascades (Schizosaccharomyces pombe)
    - Toll Like Receptor 10 (TLR10) Cascade (Schizosaccharomyces pombe)
      - MyD88 cascade initiated on plasma membrane (Schizosaccharomyces pombe)
        
        MAP kinase activation (Schizosaccharomyces pombe)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
        
        Activation of the AP-1 family of transcription factors (Schizosaccharomyces pombe)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
        
        ERK/MAPK targets (Schizosaccharomyces pombe)
        
        p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
    - Toll Like Receptor 2 (TLR2) Cascade (Schizosaccharomyces pombe)
      - Toll Like Receptor TLR1:TLR2 Cascade (Schizosaccharomyces pombe)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Schizosaccharomyces pombe)
        
        MAP kinase activation (Schizosaccharomyces pombe)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
        
        Activation of the AP-1 family of transcription factors (Schizosaccharomyces pombe)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
        
        ERK/MAPK targets (Schizosaccharomyces pombe)
        
        p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
      - Toll Like Receptor TLR6:TLR2 Cascade (Schizosaccharomyces pombe)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Schizosaccharomyces pombe)
        
        MAP kinase activation (Schizosaccharomyces pombe)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
        
        Activation of the AP-1 family of transcription factors (Schizosaccharomyces pombe)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
        
        ERK/MAPK targets (Schizosaccharomyces pombe)
        
        p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
    - Toll Like Receptor 3 (TLR3) Cascade (Schizosaccharomyces pombe)
      - MAP kinase activation (Schizosaccharomyces pombe)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
        
        Activation of the AP-1 family of transcription factors (Schizosaccharomyces pombe)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
        
        ERK/MAPK targets (Schizosaccharomyces pombe)
        
        p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
    - Toll Like Receptor 4 (TLR4) Cascade (Schizosaccharomyces pombe)
      - MyD88-independent TLR4 cascade (Schizosaccharomyces pombe)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Schizosaccharomyces pombe)
        
        MAP kinase activation (Schizosaccharomyces pombe)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
        
        Activation of the AP-1 family of transcription factors (Schizosaccharomyces pombe)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
        
        ERK/MAPK targets (Schizosaccharomyces pombe)
        
        p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Schizosaccharomyces pombe)
        
        MAP kinase activation (Schizosaccharomyces pombe)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
        
        Activation of the AP-1 family of transcription factors (Schizosaccharomyces pombe)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
        
        ERK/MAPK targets (Schizosaccharomyces pombe)
        
        p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
    - Toll Like Receptor 5 (TLR5) Cascade (Schizosaccharomyces pombe)
      - MyD88 cascade initiated on plasma membrane (Schizosaccharomyces pombe)
        
        MAP kinase activation (Schizosaccharomyces pombe)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
        
        Activation of the AP-1 family of transcription factors (Schizosaccharomyces pombe)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
        
        ERK/MAPK targets (Schizosaccharomyces pombe)
        
        p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Schizosaccharomyces pombe)
      - MyD88 dependent cascade initiated on endosome (Schizosaccharomyces pombe)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Schizosaccharomyces pombe)
        
        MAP kinase activation (Schizosaccharomyces pombe)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
        
        Activation of the AP-1 family of transcription factors (Schizosaccharomyces pombe)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
        
        ERK/MAPK targets (Schizosaccharomyces pombe)
        
        p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
    - Toll Like Receptor 9 (TLR9) Cascade (Schizosaccharomyces pombe)
      - MyD88 dependent cascade initiated on endosome (Schizosaccharomyces pombe)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Schizosaccharomyces pombe)
        
        MAP kinase activation (Schizosaccharomyces pombe)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Schizosaccharomyces pombe)
        
        Activation of the AP-1 family of transcription factors (Schizosaccharomyces pombe)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)
        
        ERK/MAPK targets (Schizosaccharomyces pombe)
        
        p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)

Signal Transduction (Schizosaccharomyces pombe)

- Signaling by Receptor Tyrosine Kinases (Schizosaccharomyces pombe)
  - Signaling by NTRKs (Schizosaccharomyces pombe)
    - Signaling by NTRK1 (TRKA) (Schizosaccharomyces pombe)
      - Nuclear Events (kinase and transcription factor activation) (Schizosaccharomyces pombe)
        
        ERK/MAPK targets (Schizosaccharomyces pombe)
        
        p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Schizosaccharomyces pombe)