Reactome | ubc4 [nucleoplasm]

ubc4 [nucleoplasm]

Stable Identifier

R-SPO-174197

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

nucleoplasm

Synonyms

UBE2D1, P46595

Locations in the PathwayBrowser

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Cell Cycle (Schizosaccharomyces pombe)

- Cell Cycle, Mitotic (Schizosaccharomyces pombe)
  - Regulation of mitotic cell cycle (Schizosaccharomyces pombe)
    - APC/C-mediated degradation of cell cycle proteins (Schizosaccharomyces pombe)
      - Regulation of APC/C activators between G1/S and early anaphase (Schizosaccharomyces pombe)
        
        Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Schizosaccharomyces pombe)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Schizosaccharomyces pombe)
        
        ubc4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Schizosaccharomyces pombe)
        
        ubc4 [nucleoplasm] (Schizosaccharomyces pombe)

Cellular responses to stimuli (Schizosaccharomyces pombe)

- Cellular responses to stress (Schizosaccharomyces pombe)
  - Cellular Senescence (Schizosaccharomyces pombe)
    - Senescence-Associated Secretory Phenotype (SASP) (Schizosaccharomyces pombe)
      - CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Schizosaccharomyces pombe)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Schizosaccharomyces pombe)
        
        ubc4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Schizosaccharomyces pombe)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Schizosaccharomyces pombe)
        
        ubc4 [nucleoplasm] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:P46595

Gene Names

ubc4

Reference Genes

BioGPS Gene:2540083 ubc4

ENSEMBL:SPBC119.02

KEGG:spo:2540083 ubc4

Monarch:2540083 ubc4

NCBI Gene:2540083 ubc4

PomBase:SPBC119.02

UCSC:P46595 ubc4

Reference Transcript

RefSeq:NM_001021190.2 ubc4

Participates

as a component of

phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Schizosaccharomyces pombe)

Other forms of this molecule

ubc4 [cytosol]

Inferred From

UBE2D1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_595283.1

PRO

P46595

PDB

9B5F, 9B5D, 9B5J, 9B5E, 9B5G, 4II2, 9B5I, 9B5C, 9B5H, 9B5K, 9B59, 9B58, 9B57, 9B55, 9B5V, 9B5T, 9B56, 9B5O, 9B5M, 9B5N, 9B5L, 9B5X, 9B5Q, 9B5S, 9B5R, 9B5P, 9B5W, 9B5U, 9B5B, 9B5A

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