CYTB binds heme and CBP4

Stable Identifier
R-SCE-9866071
Type
Reaction [omitted]
Species
Saccharomyces cerevisiae
Compartment
mitochondrial inner membrane
ReviewStatus
5/5
General
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PNG
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High
 | PPTX  | SBGN
CYTB binds heme and CBP4
Heme is incorporated in nascent cytochrome b (CYTB), the exact mechanism being unknown. This first hemylation likely triggers a conformational change that favors the binding of CBP4 to CYTB. This binding of CBP4 stabilizes the bound heme and allows the subsequent second hemylation (reviewed in Ndi et al., 2018; Zara et al., 2022).
Literature References
PubMed ID Title Journal Year
36142449 Assembly of the Multi-Subunit Cytochrome bc1 Complex in the Yeast Saccharomyces cerevisiae

Zara, V, De Blasi, G, Ferramosca, A

Int J Mol Sci 2022
29733856 Biogenesis of the bc1 Complex of the Mitochondrial Respiratory Chain

Ndi, M, Marin-Buera, L, Salvatori, R, Singh, AP, Ott, M

J Mol Biol 2018
Participants
Input
Output
Participates
as an event of
Orthologous Events
Intermediate 0 binds heme and UQCC3 (Homo sapiens)
Authored
Stephan, R  (2024-03-21)
Reviewed
Hill, DP  (2024-05-16)
Created
Stephan, R  (2024-03-21)
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