Reactome | ATP6V1B1 [cytosol]

ATP6V1B1 [cytosol]

Stable Identifier

R-SCE-912604

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

P16140

Locations in the PathwayBrowser

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Cellular responses to stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - Cellular response to starvation (Saccharomyces cerevisiae)
    - Amino acids regulate mTORC1 (Saccharomyces cerevisiae)
      - RRAGA,B hydrolyzes GTP (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B trimer [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B1 [cytosol] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B trimer [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B1 [cytosol] (Saccharomyces cerevisiae)
      - RRAGC,D exchanges GTP for GDP (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B trimer [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B1 [cytosol] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B trimer [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B1 [cytosol] (Saccharomyces cerevisiae)
      - RRAGC,D hydrolyzes GTP (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B trimer [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B1 [cytosol] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B trimer [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B1 [cytosol] (Saccharomyces cerevisiae)
      - mTORC1 binds RHEB:GTP (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B trimer [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B1 [cytosol] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B trimer [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B1 [cytosol] (Saccharomyces cerevisiae)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B trimer [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B1 [cytosol] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B trimer [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B1 [cytosol] (Saccharomyces cerevisiae)

Immune System (Saccharomyces cerevisiae)

- Innate Immune System (Saccharomyces cerevisiae)
  - ROS and RNS production in phagocytes (Saccharomyces cerevisiae)
    - Intraphagosomal pH is lowered to 5 by V-ATPase (Saccharomyces cerevisiae)
      - V-ATPase [phagocytic vesicle membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B trimer [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B1 [cytosol] (Saccharomyces cerevisiae)

Signal Transduction (Saccharomyces cerevisiae)

- Signaling by Receptor Tyrosine Kinases (Saccharomyces cerevisiae)
  - Signaling by Insulin receptor (Saccharomyces cerevisiae)
    - Insulin receptor recycling (Saccharomyces cerevisiae)
      - Endosome acidification (Saccharomyces cerevisiae)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Saccharomyces cerevisiae)
        
        V-ATPase [endosome membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B trimer [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B1 [cytosol] (Saccharomyces cerevisiae)

Transport of small molecules (Saccharomyces cerevisiae)

- Iron uptake and transport (Saccharomyces cerevisiae)
  - Transferrin endocytosis and recycling (Saccharomyces cerevisiae)
    - Acidification of Tf:TfR1 containing endosome (Saccharomyces cerevisiae)
      - V-ATPase:ATP6AP1 [endosome membrane] (Saccharomyces cerevisiae)
        
        V-ATPase [endosome membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B trimer [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1B1 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P16140

Reference Genes

BioGPS Gene:852424

ENSEMBL:YBR127C

KEGG:sce:YBR127C

Monarch:852424

NCBI Gene:852424

SGD:YBR127C

UCSC:P16140

Reference Transcript

RefSeq:NM_001178475.3

Other Identifiers

852424

GO:0000139

GO:0000166

GO:0000221

GO:0000329

GO:0000425

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005737

GO:0005773

GO:0005774

GO:0006811

GO:0006873

GO:0006874

GO:0007035

GO:0008150

GO:0010494

GO:0016020

GO:0016471

GO:0016787

GO:0022857

GO:0033176

GO:0033180

GO:0043167

GO:0045121

GO:0046034

GO:0046961

GO:0048388

GO:0055085

GO:0055086

GO:0061795

GO:0070925

GO:1902600

GO:1902906

GO:1990816

Participates

as a member of

ATP6V1B [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

ATP6V1B2 [cytosol]

Inferred From

ATP6V1B1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_009685.3

ENSEMBL

YBR127C, YBR127C, YBR127C_mRNA

PRO

P16140

PDB

7TMQ, 7TMP, 7TMR, 5BW9, 7FDE, 5VOY, 5VOX, 7FDB, 7FDA, 7FDC, 7TMM, 9COP, 7TMO, 3J9T, 6O7V, 6O7W, 5D80, 3J9U, 5VOZ, 6O7X, 3J9V

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32589	5	SSE1 [nucleoplasm] (R-SCE-5252053) SSE1 [nucleoplasm] (R-SCE-5251998) SSE1 [cytosol] (R-SCE-5251943) SSE1 [cytosol] (R-SCE-5251946) SSE1 [cytosol] (R-SCE-3299412)	0.527	2
UniProt:P18851	3	STE4 [cytosol] (R-SCE-6814200) STE4 [cytosol] (R-SCE-6814203) STE4 [cytosol] (R-SCE-6814204)	0.527	2
UniProt:P38217	1	KAP104 [cytosol] (R-SCE-180743)	0.527	2
UniProt:P04819	1	LIG1 [nucleoplasm] (R-SCE-53787)	0.527	2

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