Reactome | VMA10 [cytosol]

VMA10 [cytosol]

Stable Identifier

R-SCE-912578

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

ATP6V1G1, P48836

Locations in the PathwayBrowser

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Cellular responses to stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - Cellular response to starvation (Saccharomyces cerevisiae)
    - Amino acids regulate mTORC1 (Saccharomyces cerevisiae)
      - RRAGA,B hydrolyzes GTP (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1G dimer [cytosol] (Saccharomyces cerevisiae)
        
        VMA10 [cytosol] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1G dimer [cytosol] (Saccharomyces cerevisiae)
        
        VMA10 [cytosol] (Saccharomyces cerevisiae)
      - RRAGC,D exchanges GTP for GDP (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1G dimer [cytosol] (Saccharomyces cerevisiae)
        
        VMA10 [cytosol] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1G dimer [cytosol] (Saccharomyces cerevisiae)
        
        VMA10 [cytosol] (Saccharomyces cerevisiae)
      - RRAGC,D hydrolyzes GTP (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1G dimer [cytosol] (Saccharomyces cerevisiae)
        
        VMA10 [cytosol] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1G dimer [cytosol] (Saccharomyces cerevisiae)
        
        VMA10 [cytosol] (Saccharomyces cerevisiae)
      - mTORC1 binds RHEB:GTP (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1G dimer [cytosol] (Saccharomyces cerevisiae)
        
        VMA10 [cytosol] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1G dimer [cytosol] (Saccharomyces cerevisiae)
        
        VMA10 [cytosol] (Saccharomyces cerevisiae)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1G dimer [cytosol] (Saccharomyces cerevisiae)
        
        VMA10 [cytosol] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1G dimer [cytosol] (Saccharomyces cerevisiae)
        
        VMA10 [cytosol] (Saccharomyces cerevisiae)

Signal Transduction (Saccharomyces cerevisiae)

- Signaling by Receptor Tyrosine Kinases (Saccharomyces cerevisiae)
  - Signaling by Insulin receptor (Saccharomyces cerevisiae)
    - Insulin receptor recycling (Saccharomyces cerevisiae)
      - Endosome acidification (Saccharomyces cerevisiae)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Saccharomyces cerevisiae)
        
        V-ATPase [endosome membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1G dimer [cytosol] (Saccharomyces cerevisiae)
        
        VMA10 [cytosol] (Saccharomyces cerevisiae)

Transport of small molecules (Saccharomyces cerevisiae)

- Iron uptake and transport (Saccharomyces cerevisiae)
  - Transferrin endocytosis and recycling (Saccharomyces cerevisiae)
    - Acidification of Tf:TfR1 containing endosome (Saccharomyces cerevisiae)
      - V-ATPase:ATP6AP1 [endosome membrane] (Saccharomyces cerevisiae)
        
        V-ATPase [endosome membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        ATP6V1G dimer [cytosol] (Saccharomyces cerevisiae)
        
        VMA10 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P48836

Gene Names

VMA10

Reference Genes

BioGPS Gene:856435 VMA10

ENSEMBL:YHR039C-A

KEGG:sce:YHR039C-A VMA10

Monarch:856435 VMA10

NCBI Gene:856435 VMA10

SGD:YHR039C-A

UCSC:P48836 VMA10

Reference Transcript

RefSeq:NM_001180027.1 VMA10

Other Identifiers

856435

GO:0000139

GO:0000221

GO:0000329

GO:0005515

GO:0005575

GO:0005773

GO:0005774

GO:0006811

GO:0006873

GO:0007035

GO:0008150

GO:0008553

GO:0016020

GO:0016471

GO:0016787

GO:0016887

GO:0022857

GO:0033176

GO:0046961

GO:0048388

GO:0055085

GO:0061795

GO:1902600

Participates

as a component of

ATP6V1G dimer [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

VMA10 [cytosol]

Inferred From

ATP6V1G [cytosol] (Homo sapiens)

ATP6V1G1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_011905.1

ENSEMBL

YHR039C-A, YHR039C-A, YHR039C-A_mRNA

PRO

P48836

PDB

2K88, 5BW9, 7TMS, 7FDB, 7FDA, 7TMT, 7FDC, 9COP, 3J9T, 5D80, 5VOZ, 3J9U, 3J9V, 7TMQ, 7TMP, 7TMR, 7FDE, 5VOY, 5VOX, 2KWY, 4DL0, 7TMM, 7TMO, 4EFA, 6O7W, 6O7V, 6O7X

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P39109	5	ABCC6 [plasma membrane] (R-SCE-1454922-2) ABCC9 [plasma membrane] (R-SCE-1369054-2) ABCC3 [plasma membrane] (R-SCE-194172) ABCC2 [plasma membrane] (R-SCE-375571-2) ABCC1 [plasma membrane] (R-SCE-266068-2)	0.547	2

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