PEX1:PEX6:PEX15:Ub:PEX5:PEX14:PEX13:PEX17:PEX1:PEX6:PEX15 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX17:PEX1:PEX6:PEX15

Stable Identifier
R-SCE-9033756
Type
Reaction [omitted]
Species
Saccharomyces cerevisiae
Compartment
peroxisomal membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PEX1:PEX6:PEX15:Ub:PEX5:PEX14:PEX13:PEX17:PEX1:PEX6:PEX15 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX17:PEX1:PEX6:PEX15
Ubiquitinated PEX5 (Ub:PEX5) is released from the peroxisomal membrane and interaction with the Docking and Translocation Module by PEX1:PEX6:PEX15 (the peroxisomal AAA ATPase complex, receptor export module) (Platta et al. 2005, Rosenkranz et al. 2006). Yeast PEX1 and PEX6 form a cytosolic hexameric ring that is anchored to the peroxisomal membrane by PEX15, the functional orthologue of human PEX26. Hydrolysis of ATP by PEX1 and PEX6 appears to cause a conformational change in PEX1:PEX6:PEX15 that removes Ub:PEX5 from the peroxisomal membrane and into the cytosol (reviewed in Saffert et al. 2017). Note that yeast PEX17 does not appear to have a homolog in humans.
Literature References
PubMed ID Title Journal Year
16007078 Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol

Platta, HW, Grunau, S, Rosenkranz, K, Girzalsky, W, Erdmann, R

Nat. Cell Biol. 2005
16911527 Functional association of the AAA complex and the peroxisomal importomer

Rosenkranz, K, Birschmann, I, Grunau, S, Girzalsky, W, Kunau, WH, Erdmann, R

FEBS J. 2006
28611990 Structure and Function of p97 and Pex1/6 Type II AAA+ Complexes

Saffert, P, Enenkel, C, Wendler, P

Front Mol Biosci 2017
Participants
Input
Output
Orthologous Events
PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12 (Homo sapiens)
Authored
May, B  (2017-12-24)
Reviewed
Fransen, M  (2018-02-13)
Van Veldhoven, PP  (2018-02-13)
Azevedo, JE  (2018-03-12)
Created
May, B  (2017-12-28)
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