Reactome | RPL35B [cytosol]

RPL35B [cytosol]

Stable Identifier

R-SCE-72460-2

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

RPL35, P0CX85

Locations in the PathwayBrowser

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Metabolism of RNA (Saccharomyces cerevisiae)

- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of RPL35 [cytosol] (Saccharomyces cerevisiae)
        
        RPL35B [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of RPL35 [cytosol] (Saccharomyces cerevisiae)
        
        RPL35B [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of RPL35 [cytosol] (Saccharomyces cerevisiae)
        
        RPL35B [cytosol] (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of RPL35 [cytosol] (Saccharomyces cerevisiae)
        
        RPL35B [cytosol] (Saccharomyces cerevisiae)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of RPL35 [cytosol] (Saccharomyces cerevisiae)
        
        RPL35B [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P0CX85 RPL35B

Gene Names

RPL35B, SOS2, YDL136W, D2170

Chain

initiator methionine:, chain:2-120

Reference Genes

BioGPS Gene:851336 RPL35B

BioGPS Gene:851419 RPL35B

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YDL136W RPL35B

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YDL191W RPL35B

Monarch:851336 RPL35B

Monarch:851419 RPL35B

NCBI Gene:851336 RPL35B

NCBI Gene:851419 RPL35B

Reference Transcript

Other Identifiers

1769743_s_at

6672_s_at

851336

851419

GO:0000463

GO:0002181

GO:0003674

GO:0003723

GO:0003729

GO:0003735

GO:0005198

GO:0005575

GO:0005737

GO:0005829

GO:0005840

GO:0006364

GO:0006412

GO:0008150

GO:0022625

GO:0030687

GO:0042273

GO:1990904

Participates

as a member of

Homologues of RPL35 [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

RPL35B [cytosol]

Inferred From

RPL35 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_010090.1, NP_010145.1

PRO

P0CX85

PDB

4V8Y, 4V8Z

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