Precursor proteins enter TIM23 SORT complex

Stable Identifier
R-SCE-1268015
Type
Reaction [binding]
Species
Saccharomyces cerevisiae
Compartment
General
SVG |   | PPTX  | SBGN
Precursor proteins enter TIM23 SORT complex

The TIM23 Complex resides in the inner membrane of the mitochondrion and transfers precursor proteins to the inner membrane. The TIM23 complex appears to adopt different configurations (and perhaps different subunit compositions) depending on whether the substrate is destined for the inner membrane or the matrix. Here we refer to the TIM23 SORT complex as the configuration that delivers inner membrane proteins. The TIM21 subunit is required for this activity.The N-terminal presequence of precursors first interacts with TIM50 and TIM23 (Mokranjac et al. 2003, Martinez-Caballero et al. 2007, Tamura et al. 2009). The TIM17 and TIM23 subunits form a channel and are required to initiate translocation of precursors (Milislav et al. 2001).
Substrates of the TIM23 SORT complex targeted to the inner membrane include CYB2 (Krayl et al. 2007, Hutu et al. 2008, Popov-Celeketic et al. 2008, Tamura et al. 2009, Mokranjac et al. 2009), DLD (Mokranjac et al. 2009), ATP9 (Leuenberger et al. 1999, Milisav et al. 2001, Tamura et al. 2009), COQ2 (Leuenberger et al. 1999), TIM54 (Leuenberger et al. 1999, Kurz et al. 1999), COX4 (Martinez-Caballero et al. 2007), COX5A (Mokranjac et al. 2003), and ATP2 (Dekker et al. 1997, Mokranjac et al. 2003).

Literature References
PubMed ID Title Journal Year
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J Biol Chem 2007
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Cell 2005
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Leuenberger, D, Bally, NA, Schatz, G, Koehler, CM

EMBO J 1999
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Mol Cell Biol 2007
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J Cell Biol 2007
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Mokranjac, D, Sichting, M, Popov-Celeketi?, D, Mapa, K, Gevorkyan-Airapetov, L, Zohary, K, Hell, K, Azem, A, Neupert, W

Mol Biol Cell 2009
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Chacinska, A, van der Laan, M, Mehnert, CS, Guiard, B, Mick, DU, Hutu, DP, Truscott, KN, Wiedemann, N, Meisinger, C, Pfanner, N, Rehling, P

Mol Cell Biol 2010
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Tamura, Y, Harada, Y, Shiota, T, Yamano, K, Watanabe, K, Yokota, M, Yamamoto, H, Sesaki, H, Endo, T

J Cell Biol 2009
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Kurz, M, Martin, H, Rassow, J, Pfanner, N, Ryan, MT

Mol Biol Cell 1999
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Popov-Celeketi?, D, Mapa, K, Neupert, W, Mokranjac, D

EMBO J 2008
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EMBO J 2003
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Glick, BS, Brandt, A, Cunningham, K, Müller, S, Hallberg, RL, Schatz, G

Cell 1992
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Voos, W, von Ahsen, O, Müller, H, Guiard, B, Rassow, J, Pfanner, N

EMBO J 1996
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van der Laan, M, Meinecke, M, Dudek, J, Hutu, DP, Lind, M, Perschil, I, Guiard, B, Wagner, R, Pfanner, N, Rehling, P

Nat Cell Biol 2007
11344168 Modular structure of the TIM23 preprotein translocase of mitochondria

Milisav, I, Moro, F, Neupert, W, Brunner, M

J Biol Chem 2001
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