RNA Polymerase III Abortive Initiation

Stable Identifier
R-SCE-111943
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RNA Polymerase III Abortive Initiation
Abortive initiation, the repetitive formation of short oligonucleotides, is a ubiquitous feature of transcriptional initiation. For pol III, it has been analyzed only in S. cerevisiae (Bhargava and Kassavetis, 1999). The released products of abortive initiation, principally di- and tri-nucleotides, indicate the participation of retractive endonucleolytic cleavage of these initially forming abortive products. The transition from abortive to productive transcription may occur at bp +5.
Literature References
PubMed ID Title Journal Year
10473618 Abortive initiation by Saccharomyces cerevisiae RNA polymerase III.

Bhargava, P, Kassavetis, GA

J Biol Chem 1999
Participants
Input
Output
Orthologous Events
RNA Polymerase III Abortive Initiation At Type 3 Open Promoters (Homo sapiens)
RNA Polymerase III Abortive Initiation At Type 1 Open Promoters (Homo sapiens)
RNA Polymerase III Abortive Initiation At Type 2 Open Promoters (Homo sapiens)
Authored
Geiduschek, EP  (2004-03-29)
Created
Gillespie, ME  (2004-03-25)
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