Reactome | Rbm10 [nucleoplasm]

Rbm10 [nucleoplasm]

Stable Identifier

R-RNO-9770262

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

RBM10, P70501

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Rattus norvegicus)

- Processing of Capped Intron-Containing Pre-mRNA (Rattus norvegicus)
  - Formation of pre-mRNPs (Rattus norvegicus)
    - Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
      - Rbm10 [nucleoplasm] (Rattus norvegicus)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
      - Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
  - mRNA 3'-end processing (Rattus norvegicus)
    - mRNA Polyadenylation (Rattus norvegicus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
      - Core CPA complex binds capped pre-mRNA (Rattus norvegicus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
      - PP1 dephosphorylates RNA Pol II (Rattus norvegicus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
      - RBBP6 activates CPSF complex (Rattus norvegicus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Rattus norvegicus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
  - mRNA Splicing (Rattus norvegicus)
    - mRNA Splicing - Major Pathway (Rattus norvegicus)
      - Formation of the Spliceosomal B* complex (Rattus norvegicus)
        
        Spliceosomal B* complex [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal Bact complex [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
      - Formation of the Spliceosomal C complex containing intron lariat (Rattus norvegicus)
        
        Spliceosomal B* complex [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal C complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
      - Formation of the Spliceosomal C* complex (Rattus norvegicus)
        
        Spliceosomal C complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal C* complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
      - Formation of the Spliceosomal P complex and exon ligation (Rattus norvegicus)
        
        Spliceosomal C* complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal P complex [nucleoplasm] (Rattus norvegicus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Rattus norvegicus)
        
        Spliceosomal P complex [nucleoplasm] (Rattus norvegicus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Rbm10 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P70501

Gene Names

Rbm10

Reference Genes

BioGPS Gene:64510 Rbm10

ENSEMBL:ENSRNOG00000008472

ENSEMBL:ENSRNOG00055016541

ENSEMBL:ENSRNOG00060021559

ENSEMBL:ENSRNOG00065020441

KEGG:rno:64510 Rbm10

Monarch:64510 Rbm10

NCBI Gene:64510 Rbm10

UCSC:P70501 Rbm10

Reference Transcript

RefSeq:NM_152861.5 Rbm10

Other Identifiers

10936610

1370356_at

17875791

5677760

5846106

5849209

5994959

6019509

6052692

6113078

6113760

6164509

6182012

6195983

6234273

6260949

6279832

6293036

6303791

6352160

6400806

6418418

6433772

6438092

64510

6487319

6526127

6529903

6742778

A_44_P540065

A_44_P540067

D83948mRNA_at

GE21613

GO:0000122

GO:0000398

GO:0003676

GO:0003723

GO:0003727

GO:0005634

GO:0005730

GO:0006355

GO:0008270

GO:0008285

GO:0016071

GO:0016607

GO:0030154

GO:0032991

GO:0035198

GO:0042802

GO:0046872

GO:0048025

GO:0048255

GO:0060379

GO:0061052

GO:0070935

GO:1900119

GO:1904706

GO:1905288

GO:1905459

GO:1905461

GO:1990874

GO:2000204

ILMN_1349535

PH_rn_0004346

Participates

as a member of

Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)

Inferred From

RBM10 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_690600.1

ENSEMBL

ENSRNOP00000011317, ENSRNOG00000008472, ENSRNOT00000011317

PRO

P70501

RGD

631366

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