Reactome | Fbxo17 [cytosol]

Fbxo17 [cytosol]

Stable Identifier

R-RNO-976036

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

FBXO17, Q6AY27

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxo17 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxo17 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxo17 [cytosol] (Rattus norvegicus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxo17 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxo17 [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxo17 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxo17 [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxo17 [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxo17 [cytosol] (Rattus norvegicus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxo17 [cytosol] (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxo17 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxo17 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        SCF E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        F-box protein [cytosol] (Rattus norvegicus)
        
        Fbxo17 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q6AY27

Gene Names

Fbxo17

Reference Genes

BioGPS Gene:292757 Fbxo17

ENSEMBL:ENSRNOG00000019942

ENSEMBL:ENSRNOG00000019942.8 Fbxo17

ENSEMBL:ENSRNOG00060031734

ENSEMBL:ENSRNOG00065034046

KEGG Gene (Rattus norvegicus):292757 Fbxo17

Monarch:292757 Fbxo17

NCBI Gene:292757 Fbxo17

UCSC:Q6AY27 Fbxo17

Reference Transcript

Other Identifiers

10705560

1385040_at

17614917

292757

5641860

5706278

5898472

5941141

5973161

6238471

6239437

6599862

A_44_P379772

A_64_P027503

GO:0005515

GO:0019005

ILMN_1651086

PH_rn_0003820

Participates

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)

as a member of

F-box protein [cytosol] (Rattus norvegicus)

Inferred From

FBXO17 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_017444395.1, NP_001013082.2, XP_017444396.1

Ensembl

ENSRNOT00000027006, ENSRNOP00000027006, ENSRNOG00000019942

PRO

Q6AY27

RGD

1308308

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