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phospho-Brca1 [nucleoplasm]
Stable Identifier
R-RNO-9707290
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
K6PolyUb,p-S1387,S1423,S1457,S1524-BRCA1, O54952
Locations in the PathwayBrowser
Expand all
Cell Cycle (Rattus norvegicus)
Cell Cycle Checkpoints (Rattus norvegicus)
G2/M Checkpoints (Rattus norvegicus)
G2/M DNA damage checkpoint (Rattus norvegicus)
CHEK2 is recruited to DNA DSBs (Rattus norvegicus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Rattus norvegicus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Rattus norvegicus)
phospho-Brca1 [nucleoplasm] (Rattus norvegicus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Rattus norvegicus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Rattus norvegicus)
phospho-Brca1 [nucleoplasm] (Rattus norvegicus)
Phosphorylation and activation of CHEK2 by ATM (Rattus norvegicus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Rattus norvegicus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Rattus norvegicus)
phospho-Brca1 [nucleoplasm] (Rattus norvegicus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Rattus norvegicus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Rattus norvegicus)
phospho-Brca1 [nucleoplasm] (Rattus norvegicus)
DNA Repair (Rattus norvegicus)
DNA Double-Strand Break Repair (Rattus norvegicus)
DNA Double Strand Break Response (Rattus norvegicus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Rattus norvegicus)
CHEK2 is recruited to DNA DSBs (Rattus norvegicus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Rattus norvegicus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Rattus norvegicus)
phospho-Brca1 [nucleoplasm] (Rattus norvegicus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Rattus norvegicus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Rattus norvegicus)
phospho-Brca1 [nucleoplasm] (Rattus norvegicus)
CHEK2 phosphorylates BRCA1 (Rattus norvegicus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Rattus norvegicus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Rattus norvegicus)
phospho-Brca1 [nucleoplasm] (Rattus norvegicus)
Phosphorylation and activation of CHEK2 by ATM (Rattus norvegicus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Rattus norvegicus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Rattus norvegicus)
phospho-Brca1 [nucleoplasm] (Rattus norvegicus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Rattus norvegicus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Rattus norvegicus)
phospho-Brca1 [nucleoplasm] (Rattus norvegicus)
Phosphorylation of BRCA1-A complex at multiple sites by ATM (Rattus norvegicus)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Rattus norvegicus)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Rattus norvegicus)
phospho-Brca1 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:O54952
Gene Names
Brca1
Reference Genes
BioGPS Gene:497672 Brca1
ENSEMBL:ENSRNOG00000020701
KEGG:rno:497672 Brca1
Monarch:497672 Brca1
NCBI Gene:497672 Brca1
UCSC:O54952 Brca1
Reference Transcript
RefSeq:NM_012514.2 Brca1
Participates
as a component of
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Rattus norvegicus)
Other forms of this molecule
Brca1 [nucleoplasm]
Brca1 [nucleoplasm]
phospho-Brca1 [nucleoplasm]
Brca1 [nucleoplasm]
Brca1 [nucleoplasm]
phospho-Brca1 [nucleoplasm]
phospho-Brca1 [nucleoplasm]
Inferred From
K6PolyUb,p-S1387,S1423,S1457,S1524-BRCA1 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K6-PolyUb [nucleoplasm]) at unknown position
Modification
K6polyUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
O-phospho-L-serine at 1387 (in Homo sapiens)
Coordinate
1387
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1423 (in Homo sapiens)
Coordinate
1423
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1457 (in Homo sapiens)
Coordinate
1457
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1524 (in Homo sapiens)
Coordinate
1524
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_036646.2
PRO
O54952
RGD
2218
PDB
1L0B
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