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OPTN [cytosol]
Stable Identifier
R-RNO-9687907
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
Q8R5M4
Locations in the PathwayBrowser
Expand all
Autophagy (Rattus norvegicus)
Macroautophagy (Rattus norvegicus)
Selective autophagy (Rattus norvegicus)
Mitophagy (Rattus norvegicus)
PINK1-PRKN Mediated Mitophagy (Rattus norvegicus)
OPTN, TBK1 bind ubiquitinated MOM proteins (Rattus norvegicus)
OPTN [cytosol] (Rattus norvegicus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Rattus norvegicus)
OPTN [cytosol] (Rattus norvegicus)
TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Rattus norvegicus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Rattus norvegicus)
OPTN [cytosol] (Rattus norvegicus)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Rattus norvegicus)
OPTN [cytosol] (Rattus norvegicus)
p-S-TBK1 phosphorylates OPTN (Rattus norvegicus)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Rattus norvegicus)
OPTN [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Rattus norvegicus)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Rattus norvegicus)
OPTN binds TBK1 within the activated TLR4 complex (Rattus norvegicus)
OPTN [cytosol] (Rattus norvegicus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Rattus norvegicus)
OPTN [cytosol] (Rattus norvegicus)
TBK1 is phosphorylated within the activated TLR4 complex (Rattus norvegicus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Rattus norvegicus)
OPTN [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
TNF signaling (Rattus norvegicus)
Regulation of TNFR1 signaling (Rattus norvegicus)
OPTN binds CASP8 (Rattus norvegicus)
OPTN [cytosol] (Rattus norvegicus)
OPTN:CASP8 [cytosol] (Rattus norvegicus)
OPTN [cytosol] (Rattus norvegicus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Rattus norvegicus)
OPTN [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
OPTN [cytosol] (Rattus norvegicus)
OPTN recruits CYLD to the TNFR1 complex (Rattus norvegicus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
OPTN [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
OPTN [cytosol] (Rattus norvegicus)
TNFR1-induced NF-kappa-B signaling pathway (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
OPTN [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q8R5M4
Reference Genes
BioGPS Gene:246294
ENSEMBL:ENSRNOG00000017941
ENSEMBL:ENSRNOG00055017807
ENSEMBL:ENSRNOG00065007794
KEGG:rno:246294
Monarch:246294
NCBI Gene:246294
UCSC:Q8R5M4
Reference Transcript
RefSeq:NM_145081.3
Participates
as an input of
OPTN binds CASP8 (Rattus norvegicus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Rattus norvegicus)
OPTN binds TBK1 within the activated TLR4 complex (Rattus norvegicus)
OPTN, TBK1 bind ubiquitinated MOM proteins (Rattus norvegicus)
as a component of
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
OPTN:CASP8 [cytosol] (Rattus norvegicus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Rattus norvegicus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Rattus norvegicus)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Rattus norvegicus)
Other forms of this molecule
OPTN [recycling endosome membrane]
OPTN [Golgi membrane]
phospho-p-S177-OPTN [nucleoplasm]
phospho-p-S177-OPTN [cytosol]
phospho-p-S177,S473,S513-OPTN [cytosol]
Inferred From
OPTN [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_659549.2
PRO
Q8R5M4
RGD
628886
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